Publications

Abstract (Expand)

Archaea are characterised by a complex metabolism with many unique enzymes that differ from their bacterial and eukaryotic counterparts. The thermoacidophilic archaeon Sulfolobus solfataricus is known ...

Authors: Jacqueline Wolf, Helge Stark, Andreas Albersmeier, Trong Khoa Pham, Stefan Albaum, Theresa Kouril, Phil Wright, Sonja-Verena Albers, Dietmar Schomburg, Bettina Siebers, Fafenrot K.,Muller K. B.,Meyer B.,Hoffmann L.,Shen L.,Schmidt-Hohagen K.,Neumann-Schaal M.,Brasen C.,Kalinowski J.

Date Published: 10th Sep 2016

Journal: Mol Microbiol

Abstract (Expand)

In the presence of oxygen (O2) the model bacterium Escherichia coli is able to conserve energy by aerobic respiration. Two major terminal oxidases are involved in this process - Cyo has a relatively ...

Authors: Hao Bai, Matthew Rolfe, Wenjing Jia, Robert Poole, Jeff Green, Michael Holcombe, Coakley S.

Date Published: 24th Apr 2014

Journal: PLoS Comput Biol

Abstract (Expand)

The efficient redesign of bacteria for biotechnological purposes, such as biofuel production, waste disposal or specific biocatalytic functions, requires a quantitative systems-level understanding of ...

Authors: None

Date Published: 27th Mar 2014

Journal: Front Microbiol

Abstract (Expand)

The respiratory chain of E. coli is branched to allow the cells' flexibility to deal with changing environmental conditions. It consists of the NADH:ubiquinone oxidoreductases NADH dehydrogenase I ...

Authors: None

Date Published: 27th Jan 2014

Journal: PLoS One

Abstract (Expand)

We present an experimental and computational pipeline for the generation of kinetic models of metabolism, and demonstrate its application to glycolysis in Saccharomyces cerevisiae. Starting from an ...

Author: Smallbone K.,Messiha H. L.,Carroll K. M.,Winder C. L.,Malys N.,Dunn W. B.,Murabito E.,Swainston N.,Dada J. O.,Khan F.,Pir P.,Simeonidis E.,Spasic I.,Wishart J.,Weichart D.,Hayes N. W.,Jameson D.,Broomhead D. S.,Oliver S. G.,Gaskell S. J.,McCarthy J. E.,Paton N. W.,Westerhoff H. V.,Kell D. B.,Mendes P.

Date Published: 9th Jul 2013

Journal: FEBS Lett

Abstract (Expand)

In response to changing extracellular pH levels, phosphate-limited continuous cultures of Clostridium acetobutylicum reversibly switches its metabolism from the dominant formation of acids to the ...

Authors: None

Date Published: 3rd May 2013

Journal: Appl. Microbiol. Biotechnol.

Abstract (Expand)

To gain more insight into the butanol stress response of Clostridium acetobutylicum the transcriptional response of a steady state acidogenic culture to different levels of n-butanol (0.25-1%) was ...

Authors: Katrin Schwarz, Wouter Kuit, Armin Ehrenreich, Servé Kengen, Grimmler Christina

Date Published: 1st Mar 2012

Journal: Journal of Biotechnology

Abstract (Expand)

Common laboratory strains of Bacillus subtilis encode two glutamate dehydrogenases: the enzymatically active protein RocG and the cryptic enzyme GudB that is inactive due to a duplication of three amino ...

Authors: Joerg Stuelke, Gunka Katrin,Tholen Stefan,Gerwig Jan,Herzberg Christina,Commichau Fabian M

Date Published: 16th Dec 2011

Journal: J. Bacteriol.

Abstract (Expand)

One of the main pathways for the detoxification of reactive metabolites in the liver involves glutathione conjugation. Metabolic profiling studies have shown paradoxical responses in glutathione-related ...

Authors: Franco Du Preez, Hans Westerhoff, Jacky Snoep, Geenen Suzanne,Reed Michael,Nijhout H Frederik,Kenna J Gerry,Wilson Ian D

Date Published: 24th Aug 2011

Journal: Eur J Pharm Sci

Abstract (Expand)

Bacterial promoters are recognized by RNA polymerase (RNAP) σ subunit, which specifically interacts with the -10 and -35 promoter elements. Here, we provide evidence that the β' zipper, an ...

Authors: Yulia Yuzenkova, Nikolay Zenkin, Tadigotla Vasisht R,Severinov Konstantin

Date Published: 26th Jul 2011

Journal: EMBO J.

Abstract (Expand)

As a versatile pathogen Staphylococcus aureus can cause various disease patterns, which are influenced by strain specific virulence factor repertoires but also by S. aureus physiological adaptation ...

Authors: Uwe Voelker, Michael Hecker, Michael Lalk, Liebeke Manuel,Dörries Kirsten,Zühlke Daniela,Bernhardt Jörg,Fuchs Stephan,Pané-Farré Jan,Engelmann Susanne,Bode Rüdiger,Dandekar Thomas,Lindequist Ulrike

Date Published: 1st Apr 2011

Journal: Mol Biosyst

Abstract (Expand)

Streptomyces coelicolor, the model species of the genus Streptomyces, presents a complex life cycle of successive morphological and biochemical changes involving the formation of substrate and aerial ...

Author: Battke F.,Herbig A.,Wentzel A.,Jakobsen O. M.,Bonin M.,Hodgson D. A.,Wohlleben W.,Ellingsen T. E.,Nieselt K.

Date Published: 25th Mar 2011

Journal: Adv Exp Med Biol

Abstract (Expand)

To maintain optimal intracellular concentrations of alkali-metal-cations, yeast cells use a series of influx and efflux systems. Nonconventional yeast species have at least three different types of ...

Authors: None

Date Published: 1st Feb 2011

Journal: FEMS Microbiol. Lett.

Abstract (Expand)

Fluorescence microscopy is an imaging technique that provides insights into signal transduction pathways through the generation of quantitative data, such as the spatiotemporal distribution of GFP-tagged ...

Authors: Thomas Millat, Olaf Wolkenhauer, Frey Simone,Sott Kristin,Smedh Maria,Dahl Peter,Goksör Mattias

Date Published: 2011

Journal: Mol. BioSyst.

Abstract (Expand)

Background: Clostridium acetobutylicum is an anaerobic bacterium which is known for its solvent-producing capabilities, namely regarding the bulk chemicals acetone and butanol, the latter being a highly ...

Authors: None

Date Published: 2011

Journal: BMC Syst Biol

Abstract (Expand)

The complex changes in the life cycle of Clostridium acetobutylicum, a promising biofuel producer, are not well understood. During exponential growth, sugars are fermented to acetate and butyrate, and ...

Authors: Holger Janssen, Christina Döring, Armin Ehrenreich, Hubert Bahl, Ralf-Jörg Fischer, Voigt Birgit,Hecker Michael

Date Published: 1st Aug 2010

Journal: Appl Microbiol Biotechnol

Abstract (Expand)

The maintenance of appropriate intracellular concentrations of alkali metal cations, principally K(+) and Na(+), is of utmost importance for living cells, since they determine cell volume, intracellular ...

Authors: None

Date Published: 4th Mar 2010

Journal: Microbiol. Mol. Biol. Rev.

Abstract (Expand)

Two-component systems (TCSs) are widely employed by bacteria to sense specific external signals and conduct an appropriate response via a phosphorylation cascade within the cell. The TCS of the agr ...

Authors: Sara Jabbari, John King, Williams Paul

Date Published: 30th Nov 2009

Journal: Math Biosci

Abstract (Expand)

SUMMARY: Systems Biology Markup Language (SBML) is the leading exchange format for mathematical models in Systems Biology. Semantic annotations link model elements with external knowledge via unique ...

Authors: Falko Krause, Edda Klipp, Uhlendorf Jannis,Lubitz Timo,Schulz Marvin,Liebermeister Wolfram

Date Published: 17th Nov 2009

Journal: Bioinformatics

Abstract (Expand)

Coordination of DNA replication with cellular development is a crucial problem in most living organisms. Bacillus subtilis cells switch from vegetative growth to sporulation when starved. Sporulation ...

Authors: Jan-Willem Veening, Murray Heath,Errington Jeff

Date Published: 18th Aug 2009

Journal: Genes Dev.

Abstract (Expand)

Bacillus subtilis is a well-established cellular factory for proteins and fine chemicals. In particular, the direct secretion of proteinaceous products into the growth medium greatly facilitates their ...

Authors: Jan Maarten Van Dijl, Kouwen Thijs R H M

Date Published: 11th Jun 2009

Journal: Appl. Microbiol. Biotechnol.

Abstract (Expand)

Bacillus subtilis is the model organism for Gram-positive bacteria, with a large amount of publications on all aspects of its biology. To facilitate genome annotation and the collection of comprehensive ...

Authors: Lope A. Florez, Joerg Stuelke, Roppel Sebastian F,Schmeisky Arne G,Lammers Christoph R

Date Published: 26th May 2009

Journal: Not specified

Abstract (Expand)

Analysis of metabolome samples by gas chromatography/mass spectrometry requires a comprehensive derivatization method to afford quantitative and qualitative information of a complex biological sample. ...

Authors: Michael Lalk, Liebeke Manuel,Wunder Ariane

Date Published: 4th Feb 2009

Journal: Anal. Biochem.

Abstract (Expand)

Metabolic models have the potential to impact on genome annotation and on the interpretation of gene expression and other high throughput genome data. The genome of Streptomyces coelicolor genome has ...

Authors: David Hodgson, David Wild, Saqi Mansoor,Dobson Richard J B,Kraben Preben

Date Published: 13th Nov 2008

Journal: J Integr Bioinform

Abstract (Expand)

Calmodulin plays a vital role in mediating bidirectional synaptic plasticity by activating either calcium/calmodulin-dependent protein kinase II (CaMKII) or protein phosphatase 2B (PP2B) at different ...

Authors: Melanie Stefan, Edelstein S. J.,Le Novere N.

Date Published: 31st Jul 2008

Journal: Proc Natl Acad Sci U S A

Abstract (Expand)

Many microorganisms, including bacteria of the class Streptomycetes, produce various secondary metabolites including antibiotics to gain a competitive advantage in their natural habitat. The production ...

Authors: Eriko Takano, Mehra Sarika,Charaniya Salim,Hu Wei-Shou

Date Published: 2nd May 2008

Journal: PLoS ONE

Abstract:

Not specified

Authors: William Gaze, Elizabeth Wellington, O'Neill Colette,Hawkey Peter

Date Published: 9th Apr 2008

Journal: Adv. Appl. Microbiol.

Abstract (Expand)

Photoperiodism allows organisms to measure daylength, or external photoperiod, and to anticipate coming seasons. Daylength measurement requires the integration of light signal and temporal information ...

Author: Nakamichi N.,Kita M.,Niinuma K.,Ito S.,Yamashino T.,Mizoguchi T.,Mizuno T.

Date Published: 17th May 2007

Journal: Plant Cell Physiol

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