Abstract (Expand)

Lung cancer, with its most prevalent form non-small-cell lung carcinoma (NSCLC), is one of the leading causes of cancer-related deaths worldwide, and is commonly treated with chemotherapeutic drugs ...

Authors: R. Merkle, Bernhard Steiert, F. Salopiata, S. Depner, A. Raue, N. Iwamoto, M. Schelker, H. Hass, M. Wasch, M. E. Bohm, O. Mucke, D. B. Lipka, C. Plass, W. D. Lehmann, C. Kreutz, J. Timmer, Marcel Schilling, U. Klingmuller

Date Published: 6th Aug 2016

Journal: PLoS Comput Biol

Abstract (Expand)

Hepatitis C virus (HCV) is a major cause of chronic liver disease affecting around 130 million people worldwide. While great progress has been made to define the principle steps of the viral life cycle, ...

Authors: M. Poenisch, P. Metz, H. Blankenburg, A. Ruggieri, J. Y. Lee, D. Rupp, I. Rebhan, K. Diederich, Lars Kaderali, F. S. Domingues, M. Albrecht, V. Lohmann, H. Erfle, Ralf Bartenschlager

Date Published: 8th Jan 2015

Journal: PLoS Pathog

Abstract (Expand)

STAT5A and STAT5B are important transcription factors that dimerize and transduce activation signals of cytokine receptors directly to the nucleus. A typical cytokine that mediates STAT5 activation is ...

Authors: M. E. Boehm, Lorenz Adlung, Marcel Schilling, S. Roth, U. Klingmuller, W. D. Lehmann

Date Published: 7th Nov 2014

Journal: J Proteome Res

Abstract (Expand)

Four enzymes of the gluconeogenic pathway in Sulfolobus solfataricus were purified and kinetically characterized. The enzymes were reconstituted in vitro to quantify the contribution of temperature ...

Authors: Theresa Kouril, Dominik Esser, Julia Kort, Hans Westerhoff, Bettina Siebers, Jacky Snoep

Date Published: 20th Jul 2013

Journal: FEBS J.

Abstract (Expand)

In a continuous culture under phosphate limitation the metabolism of Clostridium acetobutylicum depends on the external pH level. By comparing seven steady-state conditions between pH 5.7 and pH 4.5 ...

Authors: None

Date Published: 1st Feb 2013

Journal: Microbial Biotechnology

Abstract (Expand)

Transcription and translation are coupled in bacteria, meaning that translation takes place co-transcriptionally. During transcription-translation, both machineries mutually affect each others' ...

Authors: Daniel Castro-Roa, Nikolay Zenkin

Date Published: 3rd Jan 2012

Journal: Nucleic acids research

Abstract (Expand)

A metabolite profiling study of the antibiotic producing bacterium Streptomyces coelicolor A3(2) has been performed. The aim of this study was to monitor intracellular metabolite pool changes occurring ...

Authors: A. Wentzel, H. Sletta, T. E. Ellingsen, P. Bruheim

Date Published: 2012

Journal: Metabolites

Abstract (Expand)

Streptococcus pyogenes (group A Streptococcus [GAS]) is a major human pathogen, causing diseases ranging from mild superficial infections of the skin and pharyngeal mucosal membrane, up to severe ...

Authors: Tomas Fiedler, Venelina Sugareva, Nadja Patenge, Bernd Kreikemeyer

Date Published: 8th Dec 2010

Journal: Future Microbiol

Abstract (Expand)

The budding yeast Saccharomyces cerevisiae grows far better at acidic than at neutral or alkaline pH. Consequently, even a modest alkalinization of the medium represents a stressful situation for this ...

Authors: None

Date Published: 20th Aug 2010

Journal: OMICS


Not specified

Authors: Seung Bum Sohn, Tae Yong Kim, Jong Myoung Park, Sang Yup Lee

Date Published: 1st Jul 2010

Journal: Biotechnology Journal

Abstract (Expand)

Phosphorylation is an important mechanism of protein modification. In the Gram-positive soil bacterium Bacillus subtilis, about 5% of all proteins are subject to phosphorylation, and a significant ...

Authors: Nico Pietack, Dörte Becher, Sebastian R Schmidl, Milton H Saier, Michael Hecker, Fabian M Commichau, Joerg Stuelke

Date Published: 13th Apr 2010

Journal: J. Mol. Microbiol. Biotechnol.

Abstract (Expand)

Pseudomonas putida is a soil microorganism that utilizes aromatic amino acids present in root exudates as a nitrogen source. We have previously shown that the PhhR transcriptional regulator induces ...

Authors: M. Carmen Herrera, Estrella Duque, José J. Rodríguez-Herva, Ana M. Fernández-Escamilla, Juan Ramos

Date Published: 2010

Journal: Not specified

Abstract (Expand)

In this article we present and test a strategy to integrate, in a sequential manner, sensitivity analysis, bifurcation analysis and predictive simulations. Our strategy uses some of these methods in a ...

Authors: S. Nikolov, X. Lai, Ulf Liebal, Olaf Wolkenhauer, J. Vera

Date Published: 2010

Journal: Int. J. of Systems Sc.

Abstract (Expand)

Bacillus subtilis strain 168 produces the extremely stable lantibiotic sublancin 168, which has a broad spectrum of bactericidal activity. Both sublancin 168 production and producer immunity are ...

Authors: Jean-Yves F Dubois, Thijs R H M Kouwen, Anna K C Schurich, Carlos R Reis, Hendrik T Ensing, Erik N Trip, Jessica C Zweers, Jan Maarten Van Dijl

Date Published: 1st Dec 2008

Journal: Antimicrob. Agents Chemother.

Abstract (Expand)

With the advent of a new generation of high-resolution mass spectrometers, the fields of proteomics and metabolomics have gained powerful new tools. In this paper, we demonstrate a novel computational ...

Authors: Richard A Scheltema, Anas Kamleh, David Wildridge, Charles Ebikeme, David G Watson, Michael P Barrett, R Jansen, Rainer Breitling

Date Published: 22nd Oct 2008

Journal: Proteomics

Abstract (Expand)

Thiol-disulfide oxidoreductases (TDORs) catalyze thiol-disulfide exchange reactions that are crucial for protein activity and stability. Specifically, they can function as thiol oxidases, disulfide ...

Authors: Thijs R H M Kouwen, Jan Maarten Van Dijl

Date Published: 30th May 2008

Journal: Trends Microbiol.


Not specified

Authors: Jochen Schaub, Carola Schiesling, Matthias Reuss, Michael Dauner

Date Published: 2006

Journal: Biotechnol Progress

Abstract (Expand)

Butyl butyrate (BB) is a valuable chemical that can be used as flavor, fragrance, extractant, and so on in various industries. Meanwhile, BB can also be used as a fuel source with excellent compatibility ...

Authors: Z. T. Zhang, S. Taylor, Y. Wang

Date Published: No date defined

Journal: Biotechnol Bioeng

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