Publications

Abstract (Expand)

Lung cancer, with its most prevalent form non-small-cell lung carcinoma (NSCLC), is one of the leading causes of cancer-related deaths worldwide, and is commonly treated with chemotherapeutic drugs ...

Authors: Bernhard Steiert, Marcel Schilling, Merkle R.,Salopiata F.,Depner S.,Raue A.,Iwamoto N.,Schelker M.,Hass H.,Wasch M.,Bohm M. E.,Mucke O.,Lipka D. B.,Plass C.,Lehmann W. D.,Kreutz C.,Timmer J.,Klingmuller U.

Date Published: 6th Aug 2016

Journal: PLoS Comput Biol

Abstract (Expand)

Hepatitis C virus (HCV) is a major cause of chronic liver disease affecting around 130 million people worldwide. While great progress has been made to define the principle steps of the viral life cycle, ...

Authors: Lars Kaderali, Ralf Bartenschlager, Poenisch M.,Metz P.,Blankenburg H.,Ruggieri A.,Lee J. Y.,Rupp D.,Rebhan I.,Diederich K.,Domingues F. S.,Albrecht M.,Lohmann V.,Erfle H.

Date Published: 8th Jan 2015

Journal: PLoS Pathog

Abstract (Expand)

STAT5A and STAT5B are important transcription factors that dimerize and transduce activation signals of cytokine receptors directly to the nucleus. A typical cytokine that mediates STAT5 activation is ...

Authors: Lorenz Adlung, Marcel Schilling, Boehm M. E.,Roth S.,Klingmuller U.,Lehmann W. D.

Date Published: 7th Nov 2014

Journal: J Proteome Res

Abstract (Expand)

Four enzymes of the gluconeogenic pathway in Sulfolobus solfataricus were purified and kinetically characterized. The enzymes were reconstituted in vitro to quantify the contribution of temperature ...

Authors: Theresa Kouril, Hans Westerhoff, Bettina Siebers, Jacky Snoep, Esser Dominik,Kort Julia

Date Published: 20th Jul 2013

Journal: FEBS J.

Abstract (Expand)

In a continuous culture under phosphate limitation the metabolism of Clostridium acetobutylicum depends on the external pH level. By comparing seven steady-state conditions between pH 5.7 and pH 4.5 ...

Authors: None

Date Published: 1st Feb 2013

Journal: Microbial Biotechnology

Abstract (Expand)

Transcription and translation are coupled in bacteria, meaning that translation takes place co-transcriptionally. During transcription-translation, both machineries mutually affect each others' ...

Authors: Nikolay Zenkin, Castro-Roa Daniel

Date Published: 3rd Jan 2012

Journal: Nucleic acids research

Abstract (Expand)

A metabolite profiling study of the antibiotic producing bacterium Streptomyces coelicolor A3(2) has been performed. The aim of this study was to monitor intracellular metabolite pool changes occurring ...

Author: Wentzel A.,Sletta H.,Ellingsen T. E.,Bruheim P.

Date Published: 2012

Journal: Metabolites

Abstract (Expand)

Streptococcus pyogenes (group A Streptococcus [GAS]) is a major human pathogen, causing diseases ranging from mild superficial infections of the skin and pharyngeal mucosal membrane, up to severe ...

Authors: Tomas Fiedler, Bernd Kreikemeyer, Sugareva Venelina,Patenge Nadja

Date Published: 8th Dec 2010

Journal: Future Microbiol

Abstract (Expand)

The budding yeast Saccharomyces cerevisiae grows far better at acidic than at neutral or alkaline pH. Consequently, even a modest alkalinization of the medium represents a stressful situation for this ...

Authors: None

Date Published: 20th Aug 2010

Journal: OMICS

Abstract:

Not specified

Author: Sohn Seung Bum,Kim Tae Yong,Park Jong Myoung,Lee Sang Yup

Date Published: 1st Jul 2010

Journal: Biotechnology Journal

Abstract (Expand)

Phosphorylation is an important mechanism of protein modification. In the Gram-positive soil bacterium Bacillus subtilis, about 5% of all proteins are subject to phosphorylation, and a significant ...

Authors: Michael Hecker, Joerg Stuelke, Pietack Nico,Becher Dörte,Schmidl Sebastian R,Saier Milton H,Commichau Fabian M

Date Published: 13th Apr 2010

Journal: J. Mol. Microbiol. Biotechnol.

Abstract (Expand)

Pseudomonas putida is a soil microorganism that utilizes aromatic amino acids present in root exudates as a nitrogen source. We have previously shown that the PhhR transcriptional regulator induces ...

Authors: Estrella Duque, Juan Ramos, Herrera M. Carmen,Rodríguez-Herva José J.,Fernández-Escamilla Ana M.

Date Published: 2010

Journal: Not specified

Abstract (Expand)

In this article we present and test a strategy to integrate, in a sequential manner, sensitivity analysis, bifurcation analysis and predictive simulations. Our strategy uses some of these methods in a ...

Authors: Ulf Liebal, Olaf Wolkenhauer, Nikolov S.,Lai X.,Vera J.

Date Published: 2010

Journal: Int. J. of Systems Sc.

Abstract (Expand)

Bacillus subtilis strain 168 produces the extremely stable lantibiotic sublancin 168, which has a broad spectrum of bactericidal activity. Both sublancin 168 production and producer immunity are ...

Authors: Jan Maarten Van Dijl, Dubois Jean-Yves F,Kouwen Thijs R H M,Schurich Anna K C,Reis Carlos R,Ensing Hendrik T,Trip Erik N,Zweers Jessica C

Date Published: 1st Dec 2008

Journal: Antimicrob. Agents Chemother.

Abstract (Expand)

With the advent of a new generation of high-resolution mass spectrometers, the fields of proteomics and metabolomics have gained powerful new tools. In this paper, we demonstrate a novel computational ...

Authors: R Jansen, Rainer Breitling, Scheltema Richard A,Kamleh Anas,Wildridge David,Ebikeme Charles,Watson David G,Barrett Michael P

Date Published: 22nd Oct 2008

Journal: Proteomics

Abstract (Expand)

Thiol-disulfide oxidoreductases (TDORs) catalyze thiol-disulfide exchange reactions that are crucial for protein activity and stability. Specifically, they can function as thiol oxidases, disulfide ...

Authors: Jan Maarten Van Dijl, Kouwen Thijs R H M

Date Published: 30th May 2008

Journal: Trends Microbiol.

Abstract:

Not specified

Authors: Matthias Reuss, Schaub Jochen,Schiesling Carola,Dauner Michael

Date Published: 2006

Journal: Biotechnol Progress

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