Not specified

Authors: None

Date Published: 24th Oct 2017

Journal: Not specified

Abstract (Expand)

Ataxia telangiectasia (A-T) is a rare autosomal recessive disease characterized by progressive neurodegeneration and cerebellar ataxia. A-T is causally linked to defects in ATM, a master regulator of ...

Authors: Evandro Fei Fang, Henok Kassahun, Deborah L. Croteau, Morten Scheibye-Knudsen, Krisztina Marosi, Huiming Lu, Raghavendra A. Shamanna, Sumana Kalyanasundaram, Ravi Chand Bollineni, Mark A. Wilson, Wendy B. Iser, Bradley N. Wollman, Marya Morevati, Jun Li, Jesse S. Kerr, Qiping Lu, Tyler B. Waltz, Jane Tian, David A. Sinclair, Mark P. Mattson, Marianne B. Nilsen, Vilhelm A. Bohr

Date Published: 1st Oct 2016

Journal: Cell Metabolism

Abstract (Expand)

BACKGROUND AND METHODOLOGY: Recently, we reported on a new class of naphthoquinone derivatives showing a promising anti-trypanosomatid profile in cell-based experiments. The lead of this series (B6, ...

Authors: S. Pieretti, Jurgen Haanstra, M. Mazet, R. Perozzo, C. Bergamini, F. Prati, R. Fato, G. Lenaz, G. Capranico, R. Brun, Barbara Bakker, P. A. Michels, L. Scapozza, M. L. Bolognesi, A. Cavalli

Date Published: 17th Jan 2013

Journal: PLoS Negl Trop Dis

Abstract (Expand)

The Twin-arginine Translocation (Tat) pathway is known to translocate fully folded proteins across bacterial, archaeal and organellar membranes. To date, the mechanisms involved in processing, proofreading ...

Authors: Vivianne J Goosens, Andreas Otto, Corinna Glasner, Carmine G Monteferrante, René van der Ploeg, Michael Hecker, Dörte Becher, Jan Maarten Van Dijl

Date Published: 22nd Dec 2012

Journal: J. Proteome Res.

Abstract (Expand)

Genes are regulated because their expression involves a fitness cost to the organism. The production of proteins by transcription and translation is a well-known cost factor, but the enzymatic activity ...

Authors: Lilia Perfeito, Stéphane Ghozzi, Johannes Berg, Karin Schnetz, Michael Lässig

Date Published: 21st Jul 2011

Journal: PLoS Genet.

Abstract (Expand)

Defects of the mitochondrial K(+)/H(+) exchanger (KHE) result in increased matrix K(+) content, swelling, and autophagic decay of the organelle. We have previously identified the yeast Mdm38 and its ...

Authors: Ludmila Zotova, Markus Aleschko, Gerhard Sponder, Roland Baumgartner, Siegfried Reipert, Monika Prinz, Rudolf Schweyen, Karin Nowikovsky

Date Published: 2nd Mar 2010

Journal: J. Biol. Chem.

Abstract (Expand)

Glycolysis is one of the most important metabolic pathways in heterotrophic organisms. Several genes encoding glycolytic enzymes are essential in many bacteria even under conditions when neither ...

Authors: Fabian M Commichau, Fabian M Rothe, Christina Herzberg, Eva Wagner, Daniel Hellwig, Martin Lehnik-Habrink, Elke Hammer, Uwe Voelker, Joerg Stuelke

Date Published: 3rd Feb 2009

Journal: Mol. Cell Proteomics

Abstract (Expand)

The computational reconstruction and analysis of cellular models of microbial metabolism is one of the great success stories of systems biology. The extent and quality of metabolic network reconstructions ...

Authors: Rainer Breitling, Dennis Vitkup, Michael P Barrett

Date Published: 21st Nov 2007

Journal: Nat. Rev. Microbiol.

Abstract (Expand)

Negative feedback control is a ubiquitous feature of biochemical systems, as is time delay between a signal and its response. Negative feedback in conjunction with time delay can lead to oscillations. ...

Authors: J. Schaber, A. Lapytsko, D. Flockerzi

Date Published: No date defined

Journal: J R Soc Interface

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