Publications

Abstract (Expand)

BACKGROUND AND METHODOLOGY: Recently, we reported on a new class of naphthoquinone derivatives showing a promising anti-trypanosomatid profile in cell-based experiments. The lead of this series (B6, ...

Authors: Jurgen Haanstra, Barbara Bakker, Pieretti S.,Mazet M.,Perozzo R.,Bergamini C.,Prati F.,Fato R.,Lenaz G.,Capranico G.,Brun R.,Michels P. A.,Scapozza L.,Bolognesi M. L.,Cavalli A.

Date Published: 17th Jan 2013

Journal: PLoS Negl Trop Dis

Abstract (Expand)

The Twin-arginine Translocation (Tat) pathway is known to translocate fully folded proteins across bacterial, archaeal and organellar membranes. To date, the mechanisms involved in processing, proofreading ...

Authors: Michael Hecker, Jan Maarten Van Dijl, Goosens Vivianne J,Otto Andreas,Glasner Corinna,Monteferrante Carmine G,van der Ploeg René,Becher Dörte

Date Published: 22nd Dec 2012

Journal: J. Proteome Res.

Abstract (Expand)

Genes are regulated because their expression involves a fitness cost to the organism. The production of proteins by transcription and translation is a well-known cost factor, but the enzymatic activity ...

Authors: Johannes Berg, Perfeito Lilia,Ghozzi Stéphane,Schnetz Karin,Lässig Michael

Date Published: 21st Jul 2011

Journal: PLoS Genet.

Abstract (Expand)

Defects of the mitochondrial K(+)/H(+) exchanger (KHE) result in increased matrix K(+) content, swelling, and autophagic decay of the organelle. We have previously identified the yeast Mdm38 and its ...

Authors: Rudolf Schweyen, Karin Nowikovsky, Zotova Ludmila,Aleschko Markus,Sponder Gerhard,Baumgartner Roland,Reipert Siegfried,Prinz Monika

Date Published: 2nd Mar 2010

Journal: J. Biol. Chem.

Abstract (Expand)

Glycolysis is one of the most important metabolic pathways in heterotrophic organisms. Several genes encoding glycolytic enzymes are essential in many bacteria even under conditions when neither ...

Authors: Uwe Voelker, Joerg Stuelke, Commichau Fabian M,Rothe Fabian M,Herzberg Christina,Wagner Eva,Hellwig Daniel,Lehnik-Habrink Martin,Hammer Elke

Date Published: 3rd Feb 2009

Journal: Mol. Cell Proteomics

Abstract (Expand)

The computational reconstruction and analysis of cellular models of microbial metabolism is one of the great success stories of systems biology. The extent and quality of metabolic network reconstructions ...

Authors: Rainer Breitling, Vitkup Dennis,Barrett Michael P

Date Published: 21st Nov 2007

Journal: Nat. Rev. Microbiol.

Abstract (Expand)

Negative feedback control is a ubiquitous feature of biochemical systems, as is time delay between a signal and its response. Negative feedback in conjunction with time delay can lead to oscillations. ...

Author: Schaber J.,Lapytsko A.,Flockerzi D.

Date Published: No date defined

Journal: J R Soc Interface

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