Abstract (Expand)

Mesenchymal stromal cells (MSCs) from human bone marrow serve as a resource for cell-based therapies in regenerative medicine. Clinical applications require standardized protocols according to good ...

Authors: Rainer Saffrich, Wuchter P.,Vetter M.,Diehlmann A.,Bieback K.,Ho A. D.,Horn P.

Date Published: 19th Feb 2016

Journal: Exp Hematol

Abstract (Expand)

Cell signaling, gene expression, and metabolism are affected by cell-cell heterogeneity and random changes in the environment. The effects of such fluctuations on cell signaling and gene expression ...

Author: Gustavsson Anna-Karin,Adiels Caroline B.,Mehlig Bernhard,Goksör Mattias

Date Published: 1st Aug 2015

Journal: Sci Rep

Abstract (Expand)

Kinetoplastea such as trypanosomatid parasites contain specialized peroxisomes that uniquely contain enzymes of the glycolytic pathway and other parts of intermediary metabolism and hence are called ...

Authors: Jurgen Haanstra, Szöör Balázs,Gualdrón-López Melisa,Michels Paul AM

Date Published: 1st Dec 2014

Journal: Current Opinion in Microbiology

Abstract (Expand)

Biomass-derived d-xylose represents an economically interesting substrate for the sustainable microbial production of value-added compounds. The industrially important platform organism Corynebacterium ...

Authors: Volker Wendisch, Stephan Noack, Radek A.,Krumbach K.,Gatgens J.,Wiechert W.,Bott M.,Marienhagen J.

Date Published: 12th Oct 2014

Journal: J Biotechnol

Abstract (Expand)

In systems biology, quantitative experimental data is the basis of building mathematical models. In most of the cases, they are stored in Excel files and hosted locally. To have a public database for ...

Authors: Ulrike Wittig, Markus Stepath, Ursula Klingmüller, Wolfgang Müller, Shi L.,Jong L.,Lucarelli P.,Mueller S.,D'Alessandro L. A.

Date Published: 4th Apr 2013

Journal: J Integr Bioinform


Not specified

Authors: Victor De Lorenzo, Nikel Pablo I.

Date Published: 2013

Journal: Metabolic Engineering

Abstract (Expand)

Determining transcriptional regulator activities is a major focus of systems biology, providing key insight into regulatory mechanisms and co-regulators. For organisms such as Escherichia coli, ...

Author: Iqbal M.,Mast Y.,Amin R.,Hodgson D. A.,Wohlleben W.,Burroughs N. J.

Date Published: 13th Mar 2012

Journal: Nucleic Acids Res

Abstract (Expand)

The development of disease may be characterized as a pathological shift of homeostasis; the main goal of contemporary drug treatment is, therefore, to return the pathological homeostasis back to the ...

Authors: Jacky Snoep, Hans Westerhoff, Kolodkin Alexey,Boogerd Fred C,Plant Nick,Bruggeman Frank J,Goncharuk Valeri,Lunshof Jeantine,Moreno-Sanchez Rafael,Yilmaz Nilgun,Bakker Barbara M,Balling Rudi

Date Published: 16th Jun 2011

Journal: Eur J Pharm Sci

Abstract (Expand)

Twin-arginine protein translocation (Tat) pathways are required for transport of folded proteins across bacterial, archaeal and chloroplast membranes. Recent studies indicate that Tat has evolved into ...

Authors: Ulrike Mäder, Colin Harwood, Michael Hecker, Jan Maarten Van Dijl, van der Ploeg René,Homuth Georg,Schaffer Marc,Denham Emma L,Monteferrante Carmine G,Miethke Marcus,Marahiel Mohamed A,Winter Theresa,Antelmann Haike

Date Published: 30th Mar 2011

Journal: PLoS ONE

Abstract (Expand)

Knowledge on absolute protein concentrations is mandatory for the simulation of biological processes in the context of systems biology. A novel approach for the absolute quantification of proteins at ...

Authors: Sandra Maass, Praveen Kumar Sappa, Uwe Voelker, Michael Hecker, Sievers Susanne,Zühlke Daniela,Kuzinski Judith,Muntel Jan,Hessling Bernd,Bernhardt Jörg,Sietmann Rabea,Becher Dörte

Date Published: 11th Mar 2011

Journal: Anal. Chem.

Abstract (Expand)

We have constructed derivatives of Streptomyces coelicolor M145 as hosts for the heterologous expression of secondary metabolite gene clusters. To remove potentially competitive sinks of carbon and ...

Author: Gomez-Escribano Juan Pablo,Bibb Mervyn J.

Date Published: 1st Mar 2011

Journal: Not specified

Abstract (Expand)

The following article describes systems biology as a merger of systems theory with cell biology. The role of modelling in the description of living cells is discussed. As an example, an abstract ...

Authors: Olaf Wolkenhauer, Hofmeyr Jan-Hendrik S.

Date Published: 1st May 2008

Journal: at - Automatisierungstechnik

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