Abstract (Expand)

Mesenchymal stromal cells (MSCs) from human bone marrow serve as a resource for cell-based therapies in regenerative medicine. Clinical applications require standardized protocols according to good ...

Authors: P. Wuchter, M. Vetter, Rainer Saffrich, A. Diehlmann, K. Bieback, A. D. Ho, P. Horn

Date Published: 19th Feb 2016

Journal: Exp Hematol

Abstract (Expand)

Cell signaling, gene expression, and metabolism are affected by cell-cell heterogeneity and random changes in the environment. The effects of such fluctuations on cell signaling and gene expression ...

Authors: Anna-Karin Gustavsson, Caroline B. Adiels, Bernhard Mehlig, Mattias Goksör

Date Published: 1st Aug 2015

Journal: Sci Rep

Abstract (Expand)

Kinetoplastea such as trypanosomatid parasites contain specialized peroxisomes that uniquely contain enzymes of the glycolytic pathway and other parts of intermediary metabolism and hence are called ...

Authors: Balázs Szöör, Jurgen Haanstra, Melisa Gualdrón-López, Paul AM Michels

Date Published: 1st Dec 2014

Journal: Current Opinion in Microbiology

Abstract (Expand)

Biomass-derived d-xylose represents an economically interesting substrate for the sustainable microbial production of value-added compounds. The industrially important platform organism Corynebacterium ...

Authors: A. Radek, K. Krumbach, J. Gatgens, Volker Wendisch, W. Wiechert, M. Bott, Stephan Noack, J. Marienhagen

Date Published: 12th Oct 2014

Journal: J Biotechnol

Abstract (Expand)

In systems biology, quantitative experimental data is the basis of building mathematical models. In most of the cases, they are stored in Excel files and hosted locally. To have a public database for ...

Authors: L. Shi, L. Jong, Ulrike Wittig, P. Lucarelli, Markus Stepath, S. Mueller, L. A. D'Alessandro, Ursula Klingmüller, Wolfgang Müller

Date Published: 4th Apr 2013

Journal: J Integr Bioinform


Not specified

Authors: Pablo I. Nikel, Victor De Lorenzo

Date Published: 2013

Journal: Metabolic Engineering

Abstract (Expand)

Determining transcriptional regulator activities is a major focus of systems biology, providing key insight into regulatory mechanisms and co-regulators. For organisms such as Escherichia coli, ...

Authors: M. Iqbal, Y. Mast, R. Amin, D. A. Hodgson, W. Wohlleben, N. J. Burroughs

Date Published: 13th Mar 2012

Journal: Nucleic Acids Res

Abstract (Expand)

The development of disease may be characterized as a pathological shift of homeostasis; the main goal of contemporary drug treatment is, therefore, to return the pathological homeostasis back to the ...

Authors: Alexey Kolodkin, Fred C Boogerd, Nick Plant, Frank J Bruggeman, Valeri Goncharuk, Jeantine Lunshof, Rafael Moreno-Sanchez, Nilgun Yilmaz, Barbara M Bakker, Jacky Snoep, Rudi Balling, Hans Westerhoff

Date Published: 16th Jun 2011

Journal: Eur J Pharm Sci

Abstract (Expand)

Twin-arginine protein translocation (Tat) pathways are required for transport of folded proteins across bacterial, archaeal and chloroplast membranes. Recent studies indicate that Tat has evolved into ...

Authors: René van der Ploeg, Ulrike Mäder, Georg Homuth, Marc Schaffer, Emma L Denham, Carmine G Monteferrante, Marcus Miethke, Mohamed A Marahiel, Colin Harwood, Theresa Winter, Michael Hecker, Haike Antelmann, Jan Maarten Van Dijl

Date Published: 30th Mar 2011

Journal: PLoS ONE

Abstract (Expand)

Knowledge on absolute protein concentrations is mandatory for the simulation of biological processes in the context of systems biology. A novel approach for the absolute quantification of proteins at ...

Authors: Sandra Maass, Susanne Sievers, Daniela Zühlke, Judith Kuzinski, Praveen Kumar Sappa, Jan Muntel, Bernd Hessling, Jörg Bernhardt, Rabea Sietmann, Uwe Voelker, Michael Hecker, Dörte Becher

Date Published: 11th Mar 2011

Journal: Anal. Chem.

Abstract (Expand)

We have constructed derivatives of Streptomyces coelicolor M145 as hosts for the heterologous expression of secondary metabolite gene clusters. To remove potentially competitive sinks of carbon and ...

Authors: Juan Pablo Gomez-Escribano, Mervyn J. Bibb

Date Published: 1st Mar 2011

Journal: Not specified

Abstract (Expand)

The following article describes systems biology as a merger of systems theory with cell biology. The role of modelling in the description of living cells is discussed. As an example, an abstract ...

Authors: Olaf Wolkenhauer, Jan-Hendrik S. Hofmeyr

Date Published: 1st May 2008

Journal: at - Automatisierungstechnik

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