Head of the group of Molecular Enzyme Technology and Biochemistry (Faculty of Chemistry) at the University of Duisburg-Essen. My research interest is on archaeal physiology with a special focuss on the central carbohydrate metabolism of (hyper)thermophilic Archaea and its regulation. The aim is to gain a systems level understanding by the combination of modern highthrouput analyses with classical biochemistry and molecular biology.
Archaea possess many novel enzymes and pathways and our aim is
Projects: HUMET Startup
Institutions: Université catholique de Louvainhttps://orcid.org/0000-0003-2040-2448
Tools: Animal models, Genetic modification, Microbiology, Integrative physiology, Glucose metabolism, Lipid metabolism, Molecular biology techniques (RNA/DNA/Protein), LPS measurments, Gut microbiota analysis
Professor Patrice D. Cani is researcher from the Belgian Fund for Scientific Research and group leader in the Metabolism and Nutrition lab at the Louvain Drug Research Institute from the UCL, Brussels, Belgium. He is WELBIO investigator and recipient of an ERC Starting Grant 2013 and a PoC ERC Grant 2016. He is laureate of the Baillet-Latour grant for medical research and the international prize of Physiology Lucien Dautrebande. His main research interests are the investigation of interactions
My research is intended to contribute to the elucidation of the physiological and molecular processes involved in the biofilm formation of acidophilic leaching bacteria with emphasis in their cell-cell communication mechanisms.
In SysMetEx, our role is to understand biofilm formation at a microscopical and OMICS levels, in order to optimize it.
Institutions: University of Milano-Bicocca
I am a PostDoc working on yeast metabolomics. During my PhD I studied the interplay between metabolism, cell cycle and signalling, mainly focusing on the Snf1/AMPK pathway. I am currently interested in studying metabolic rewiring caused by different nutrients, generating high-throughput data suitable for modelling.
I am PhD student in Wendisch lab (Bielefeld University).
Post doc. in the SysMO-LAB2 project from August 2010. I work at Nofima and the Norwegian University of Life Sciences (UMB) at Ås, Norway. My focus in SysMO-LAB2 will be on four Lactobacillus plantarum strains, diversity analysis, omics-technologies, genome scale modelling.
Background: Ph.D. in Molecular Microbiology June 2010, where I worked with Lactobacillus sakei, metabolism and diversity studies.
Roles: Project Coordinator
Expertise: genetic engineering, Streptomyces, Protein-DNA-interaction, Microarray experiments with prokaryotes, Molecular microbiology, bacterial gene regulation, regulation of gene expression, Transcriptomics, Microbiology
Tools: transcription analysis, analysis of functional genomics data, microbiology techniques, reporter gene analyses, site-directed and random mutagenesis, Mutant and Strain Construction, Molecular biology techniques (RNA/DNA/Protein), Bioconductor Packages in R, Northern analyses), Chip-chip, PCR, Microarray analysis, Transcriptomics, Genetic modification, Microbiology
Expertise: Clostridium, carbon metabolism, bacterial metabolism, Anaerobic Microbiology, Clostridial Genetics, Metabolic Engineering, Synthetic Biology, Systems Biology, Molecular Biology, Genetics, Microbiology
I'm an experimentalist 'Pre-doc' (I still have to finish my PhD thesis) and my work on the COSMIC project will focus on setting up a metabolomic analysis method for Clostridium acetobutylicum.
In the past I have worked on metabolic engineering of the same organism by disrupting genes to asses their impact on acid and solvent formation.
I'm looking forward to joining the COSMIC web-community. It hopefully will all us to stay in touch and update each other on advances in the (computer)lab.
Roles: Project Coordinator
The Veening lab is interested in phenotypic bi-stability in Streptococcus pneumoniae and its importance in virulence of this human pathogen.
Tools: molecular biological techniques (RNA/DNA techniques), protein interaction studies, DNA technology RNA technology Protein analysis Fermentation Mutagenesis, gene regulation, Proteomics (2D-PAGE), Model organisms, Proteomics, Transcriptomics, Genetic analysis, Genomics, Cell biology, Biochemistry and protein analysis, Molecular Biology, Microbiology
Optimisation of Bacillus subtilis for the secretion of heterologous proteins Therapeutic proteins (including those required for experimental purposes and clinical trials) are major products of biomanufacturing processes and considerable time and expense are expended to maximise the yield and quality of proteins produced in heterologous hosts. The production host of choice is the Gram-negative bacterium Escherichia coli for which many strains and expression systems have been developed. However,
The main area of my expertise concerns protein sorting and secretion in Gram-positive bacteria, such as Bacillus subtilis and Staphylococcus aureus.
The Gram-positive bacterium B. subtilis is well known for its high capacity to secrete proteins into the extracellular milieu, which has led to its exploitation as a "cell factory" for secreted proteins. Nevertheless, the secretion of heterologous proteins of pharmaceutical importance is frequently inefficient. This applied problem has been a major
I am a first year PhD student, working with Professor Robert Poole (University of Sheffield), Professor Jeff Green (University of Sheffield) and Dr Jamie Wood (University of York) using a systems biology approach to study respiration in Escherichia coli.
PostDoc at Wageningen University, Laboratory of Microbiology
I have a permanent position at the department of microbiology at the TU-München. As a microbiologist I am interested in the regulation of central metabolism in prokaryotic organisms with different types of energy metabolism such as Clostridia, Bacilli and acetic acid bacteria. Furthermore I worked as a software developer for several years in a bioinformatics company and I am very interested in bioinformatics and handling of large amounts of data.
Expertise: Cell physiology, regulation of gene expression, quantative biology, Protein-DNA-interaction, Microbiology/ Protein chemistry/ Molecular Biology, Bacterial Cell Biology, carbon metabolism, bacterial metabolism, functional protein expression, Bacillus subtilis
Tools: surface plasmon resonance spectroscopy, reporter gene analysis, DNA, Molecular biology techniques (RNA/DNA/Protein), Chromatography, Model organisms, Cell biology, Biochemistry and protein analysis, Microbiology
I am a research technician at the Institute of Medical Science in Aberdeen, working for Prof. Ian Booth. The topic of our workpackage deals with K+ homostasis in Escherichia coli. I am working with the protein KefF, a regulatory subunit of the potassium channel KefC.
Professor in Jinan University, Guangzhou, China.
My research interest is in the modeling of translation. Connecting various processes in translation, we can investigate the impact of different factors on protein biosynthesis and biogenesis in genome-wide scale. This may reveal various general mechanisms on control level of gene expression and folding efficiency regulation in different growth conditions.
Tools: Chemical cross-linking, Site-directed mutagenesis, Membrane protein biochemistry, Biochemistry of substrate transport. molecular biological techniques (RNA/DNA techniques analyses of transport across cell membranes heterologous e..., Molecular Biology, Microbiology
I am a biologist by training. My research career is focussed on the structure-function relationships of membrane transport systems in Escherichia coli. I am interested in understanding the mechanism of ion and solute transport across the membrane and how this influences bacterial cell survival. My work mainly focusses on the ligand-gated potassium efflux systems which are crucial for cell survival during electrophile exposure and the mechanosensitive channels involved in hypoosmotic stress
Expertise: Systems Biology, regulation of gene expression, Signal transduction in Gram-negative bacteria; Synthetic Microbiology; Single cell gene expression; Regulatory networks; biochemistry; histidine ki..., gene regulation, stress responses, sporulation, phenotypic heterogeneity, bistability, translational control of gene expression, Bacillus subtilis, Molecular Biology, Genetics, Microbiology
Tools: Time-lapse fluorescence microscopy Flow cytometry, Molecular biology techniques (RNA/DNA), time lapse microscopy, Fluorecence based reporter gene analyses/single cell analyses, PCR, Model organisms, Single Cell analysis, Genetic analysis, Genetic modification, Molecular Biology, Genetics, Microbiology
Tools: SubtiWiki, SPINE, bacterial two-hybrid system, Chemical cross-linking, Proteomics (2D-PAGE), mutant strain generation, Genetic analysis, Genetic modification, Biochemistry and protein analysis, Molecular Biology, Microbiology