Institutions: University of Edinburghorcid.org/0000-0003-0737-2408
Institutions: German Cancer Research Center (DKFZ)orcid.org/0000-0002-0971-2309
Projects: HUMET Startup
Institutions: Centro de Investigación Príncipe Felipeorcid.org/0000-0003-3318-120X
Roles: Not specified
Tools: Bioinformatics, Computational and theoretical biology, Computational Systems Biology, Data Management, Databases, Dynamic modelling, Genetics, Genomics, R, Systems Biology, Transcriptomics, Java
My scientific interests revolve around functional genomics, systems biology and the development of algorithms and software for the analysis of high-throughput data (mainly, but not restricted to, Next Generation Sequencing) and its application to the relationship between genotype and phenotype, mainly oriented to personalized and precision medicine. I am especially interested in the study of disease mechanisms and drug action mechanisms, drug repositioning and the definition of mechanism-based
I am an emeritus professor in Biochemistry at the University of Amsterdam (retired 2010).
My research focussed on the human chromatin in its natural environment, i.e. the nucleus of cultured living human cells.
Aspects, such as the dynamic folding of the chromatin fiber inside the nucleus and local chemical modification of histones and DNA at genetic loci, are the physical and chemical basis for epigenetic regulation of gene expression. In my group we worked parallel on human