Head of the group of Molecular Enzyme Technology and Biochemistry (Faculty of Chemistry) at the University of Duisburg-Essen. My research interest is on archaeal physiology with a special focuss on the central carbohydrate metabolism of (hyper)thermophilic Archaea and its regulation. The aim is to gain a systems level understanding by the combination of modern highthrouput analyses with classical biochemistry and molecular biology.
Archaea possess many novel enzymes and pathways and our aim is
Institutions: National Institute of Biologyhttps://orcid.org/0000-0002-1669-6482
Roles: PhD Student
Expertise: Data analysisMathematical modellingBioinformaticsSystems biology, Data Management, Data analysis, Data integration, Visualization, computational biology, Molecular Biology, Statistics, Bioinformatics, Mathematical and statistical modeling, Programming
Tools: Bioinformatics, Computational and theoretical biology, Computational Systems Biology, Data integration, Data Management, Databases, Dynamic modelling, Molecular Biology, Python, R, Systems Biology
Computational Biologist, Young Researcher at Department of Biotechnology and Systems Biology, National Institute of Biology NIB and PhD candidate in Statistics, Ljubljana, Slovenia
Projects: HYp - Spatiotemporal analysis of hypersensitive response to Potato virus Y in potato, pISA-tree, MOA - Multiomics analysis of potato response to Potato virus Y (PVY) infection, SUSPHIRE - Sustainable Bioproduction of Pheromones for Insect Pest Control in Agriculture, INDIE - Biotechnological production of sustainable indole, FAIRDOM user meeting
Institutions: National Institute of Biologyhttps://orcid.org/0000-0001-5906-8569
Institutions: University of Edinburghhttps://orcid.org/0000-0003-0737-2408
Projects: HUMET Startup
Institutions: Centro de Investigación Príncipe Felipehttps://orcid.org/0000-0003-3318-120X
Tools: Bioinformatics, Computational and theoretical biology, Computational Systems Biology, Data Management, Databases, Dynamic modelling, Genetics, Genomics, R, Systems Biology, Transcriptomics, Java
My scientific interests revolve around functional genomics, systems biology and the development of algorithms and software for the analysis of high-throughput data (mainly, but not restricted to, Next Generation Sequencing) and its application to the relationship between genotype and phenotype, mainly oriented to personalized and precision medicine. I am especially interested in the study of disease mechanisms and drug action mechanisms, drug repositioning and the definition of mechanism-based
I am an emeritus professor in Biochemistry at the University of Amsterdam (retired 2010).
My research focussed on the human chromatin in its natural environment, i.e. the nucleus of cultured living human cells.
Aspects, such as the dynamic folding of the chromatin fiber inside the nucleus and local chemical modification of histones and DNA at genetic loci, are the physical and chemical basis for epigenetic regulation of gene expression. In my group we worked parallel on human