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Expertise: genetic engineering, Streptomyces, Protein-DNA-interaction, Microarray experiments with prokaryotes, Molecular microbiology, bacterial gene regulation, regulation of gene expression, Transcriptomics, Microbiology
Tools: transcription analysis, analysis of functional genomics data, microbiology techniques, reporter gene analyses, site-directed and random mutagenesis, Mutant and Strain Construction, Molecular biology techniques (RNA/DNA/Protein), Bioconductor Packages in R, Northern analyses), Chip-chip, PCR, Microarray analysis, Transcriptomics, Genetic modification, Microbiology
Global metabolic switching in Streptomyces coelicolor
Antibiotics are made during the second phase of growth when there is a transition in metabolism from primary to secondary metabolism. Primary metabolism is growth related and involves all the normal cellular activities associated with cell growth and division. Whereas secondary metabolism is non-growth linked and is non-essential but many important activities occur during this phase which help the bacterium survive.