ZucAt

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ZucAt - Sucrose (from german Zucker) translocation in Arabidopsis thaliana. Sucrose translocation between plant tissues is crucial for growth, development and reproduction of plants. Systemic analysis of this metabolic process and underlying regulatory processes can help to achieve better understanding of carbon distribution within the plant and the formation of phenotypic traits. Sucrose translocation from ‘source’ tissues (e.g. mesophyll) to ‘sink’ tissues (e.g. root) is tightly bound to the proton gradient across the membranes. The plant sucrose transporters are grouped into efflux exporters (SWEET family) and proton-symport importers (SUC, STP families). To better understand the regulatory connections between sucrose export from source tissues and sucrose import into sink tissues, there is a need for a metabolic model that takes in account the tissue organisation of Arabidopsis thaliana with corresponding metabolic specificities of respective tissues in terms of sucrose and proton production/utilization. An ability of the model to operate under different light modes (‘light’ and ‘dark’) and correspondingly in different energy producing modes is additional validating feature.

The model was developed in Insilico Discovery™ (Insilico Biotechnology AG, Stuttgart, Germany; http://www.insilico-biotechnology.com/), the Flux Balance Analysis was also solved with Insilico Discovery™. The final version of the model was exported in SBML (version 2, level 2) and MATLAB, and accompanying results were exported in ACSII format.

Programme: de.NBI Systems Biology Service Center (de.NBI-SysBio)

SEEK ID: https://fairdomhub.org/projects/37

Public web page: Not specified

Organisms: Arabidopsis thaliana

FAIRDOM PALs: Maksim Zakhartsev

Project created: 21st Dec 2015

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Ilya Akberdin

Projects: ZucAt, Modelling COVID-19 epidemics

Institutions: Institute of Cytology and Genetics, Novosibirsk State University

Expertise: Systems Biology, molecular genetic systems, gene networks, gene expression, Modeling

Tools: Java, Vaadin, Kinetic Modeling

I am staff scientist in the lab of molecular-genetic systems at the Department of Systems Biology, Institute of Cytology and Genetics SB RAS and Postdoc Research Fellow at San Diego State University. My research focus is dynamical modeling of gene network functioining.

Olga Krebs

Projects: SysMO DB, FAIRDOM, ICYSB 2015 - International Practical Course in Systems Biology, ZucAt, SysMO-LAB, Kinetics on the move - Workshop 2016, Example use cases, FAIRDOM user meeting, ErasysApp Funders, EraCoBiotech 2 nd call proposal preparation, Service to URV Tarragona, Spain with respect to their Safety Assessment of Endocrine Disrupting Chemicals model (Active NOW), FAIRDOM & LiSyM & de.NBI Data Structuring Training, MESI-STRAT, INCOME, Multiscale modelling of state transitions in the host-microbiome-brain network, BESTER, TRALAMINOL, Sustainable co-production, INDIE - Biotechnological production of sustainable indole, Extremophiles metabolsim, PoLiMeR - Polymers in the Liver: Metabolism and Regulation, OLCIR: Optimization of Lung Cancer Therapy with Ionizing Radiation, NAD COMPARTMENTATION, HOTSOLUTE, Stress granules, FAIRDOM Community Workers, GMDS Project Group "FAIRe Dateninfrastrukturen für die Biomedizinische Informatik", Mechanism based modeling viral disease ( COVID-19 ) dynamics in human population, COVID-19 Disease Map, AquaHealth (ERA-BlueBio), LiSyM Core Infrastructure and Management (LiSyM-PD), Early Metabolic Injury (LiSyM-EMI - Pillar I), Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF - Pillar III), Chronic Liver Disease Progression (LiSyM-DP - Pillar II), Liver Function Diagnostics (LiSyM-LiFuDi - Pillar IV), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), Modelling COVID-19 epidemics, SNAPPER: Synergistic Neurotoxicology APP for Environmental Regulation, SCyCode The Autotrophy-Heterotrophy Switch in Cyanobacteria: Coherent Decision-Making at Multiple Regulatory Layers, SASKit: Senescence-Associated Systems diagnostics Kit for cancer and stroke, CC-TOP, BioCreative VII, MESI-STRAT Review, SDBV/HITS, MESI-Review 2024

Institutions: Heidelberg Institute for Theoretical Studies (HITS gGmbH), FAIRDOM User meeting, Norwegian University of Science and Technology, University of Rostock, University of Innsbruck

https://orcid.org/0000-0003-3540-0402

Expertise: Genetics, Molecular Biology, Bioinformatics, Data Management, Transcriptomics, semantics, Curation, Ontology, Data Modelling

Tools: Cell and tissue culture, Databases, Chip-chip, BioMart, Protege, RightField, SEEK

I am a researcher at the Scientific Databases and Visualization Group at Heidelberg Institute for Theoretical Studies (HITS) , one of the developers of SabioRK - System for the Analysis of Biochemical Pathways - Reaction Kinetics (http://sabiork.h-its.org/) . I am working on design and maintenance of the information systems to store, query and analyse systems biology data; definition and implementation of methods for the integration of data from multiple sources. In **[SySMO-DB ...

Irina Medvedeva

Projects: ZucAt

Institutions: Novosibirsk State University

Expertise: Bioinformatics, Molecular Biology, protein structure

Tools: R package, MySQL, Perl

I got my Master’s Degree in Biomathematics, Bioinformatics, and Computational Biology 2007 at Novosibirsk State University (NSU). I am working at Computer Proteomics Laboratory, Institute of Cytology and Genetics SB RAS. We develope computer system to analyze the coding features of functional sites by taking into account the exon structure of the gene, to detect the exons involved in shuffling in protein evolution, also to design protein-engineering experiments. Tools developed - SitEx http://www-bionet ...

Yuriy Orlov

Projects: ZucAt

Institutions: Institute of Cytology and Genetics, Novosibirsk State University

Expertise: computational genomics, Computational Biology

Tools: high-throughput sequencing, ChIP-seq

I am Senior Scientist at Institute of Cytology and Genetics SB RAS in Novosibirsk. My research focus is computational genomics: high-throughput sequencing, ChIP-seq, human genome research (HUGO member), high performance computing in bioinformatics

Waltraud Schulze

Projects: ZucAt

Institutions: University of Hohenheim

Maksim Zakhartsev

Projects: MOSES, ExtremoPharm, ZucAt, GenoSysFat, DigiSal, EraCoBiotech 2 nd call proposal preparation, FAIRDOM & LiSyM & de.NBI Data Structuring Training

Institutions: University of Stuttgart, University of Hohenheim, Norwegian University of Life Sciences, Norwegian University of Science and Technology

https://orcid.org/0000-0002-7973-9902

I've become a SysMO DB PAL for MOSES project in 2007 being a post-doc in lab of Prof. Matthias Reuss at University of Stuttgart. In the MOSES project, our major efforts were in the experimental data acquisition for dynamic model of primary carbon and anaerobic energy metabolism in yeast. The model implements prediction of perturbations of two types: glucose pulse and temperature jump. We implement “stimulus-response” methodology for the unraveling the dynamic structure of the network and to ...

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de.NBI Systems Biology Service Center (de.NBI-SysBio)

The German Network for Bioinformatics Infrastructure - de.NBI offers first class bioinformatics services including training and education to users in basic and applied life sciences research. In this network 40 projects belonging to eight service centers provide services that cover a wide variety of methods (genomics, proteomics, ...) and applications (from plants to humans). de.NBI-SysBio is the Systems Biology Service Center of de.NBI. In collaboration with FAIRDOM, de.NBI-SysBio serves the ...

Projects: de.NBI-SysBio, ExtremoPharm, ZucAt, Kinetics on the move - Workshop 2016, Example use cases, MIX-UP, Working Group Nicole Radde, MPIEvolBio-SciComp, SABIO-VIS

Web page: http://www.denbi.de

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Heidelberg Institute for Theoretical Studies (HITS gGmbH)

Country: Germany

City: Heidelberg

Web page: http://www.h-its.org/

Institute of Cytology and Genetics

Country: Russian Federation

City: Novosibirsk

Web page: http://www.bionet.nsc.ru/en

Novosibirsk State University

Country: Russian Federation

City: Novosibirsk

Web page: http://www.nsu.ru/exp/index.jz?lang=en

University of Hohenheim

Country: Germany

City: Stuttgart

Web page: https://www.uni-hohenheim.de/

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Metabolic analysis of effects of sucrose translocation on phenotypic traits of Arabidopsis thaliana

ZucAt

Sucrose translocation between plant tissues is crucial for growth, development and reproduction of plants. Systemic analysis of this metabolic process and underlying regulatory processes can help to achieve better understanding of carbon distribution within the plant and the formation of phenotypic traits. Sucrose translocation from ‘source’ tissues (e.g. mesophyll) to ‘sink’ tissues (e.g. root) is tightly bound to the proton gradient across the membranes. The plant sucrose transporters are grouped ...