MESI-STRAT
OverviewMESI-STRAT: Systems Medicine of Metabolic-Signaling Networks -A New Concept for Breast Cancer Patient Stratification.
Breast cancer is a complex disease with high prevalence in the European Union and world-wide. 75%-80 of the patients have estrogen receptor-positive (ER)-positive tumors and are treated with endocrine therapies. Endocrine therapies, which block ER-driven tumor growth, show high efficacy. Yet, a significant proportion of the patients will eventually relapse with metastatic breast cancer, and the recurrence rates remain almost constant for up to 20 years. MESI-STRAT develops metabolite marker panels measurable in biological fluids to enable patient stratification, resistance monitoring and clinical decision-making throughout endocrine therapy. This is a new concept as breast cancer metabolism is poorly explored for diagnostics and therapy. Upon successful validation in preclinical models, the predictive marker panels and related treatments will be jointly investigated by MESI-STRAT’s clinical and industrial partners. The MESI-STRAT consortium explores the interplay of breast cancer metabolism and oncogenic signaling (MEtabolic SIgnaling) by systems medicine approaches. MESI-STRAT develops new models for knowledge-based STRATification of patients into subgroups with different endocrine therapy resistance mechanisms.
Programme: This Project is not associated with a Programme
SEEK ID: https://fairdomhub.org/projects/99
Public web page: http://www.mesi-strat.eu
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus
FAIRDOM PALs: No PALs for this Project
Project created: 26th Feb 2018
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Institutions: Heidelberg Institute for Theoretical Studies (HITS gGmbH), FAIRDOM User meeting, Norwegian University of Science and Technology
https://orcid.org/0000-0003-3540-0402
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Projects: MESI-STRAT
Institutions: University of Groningen
MESI-STRAT Project Manager
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Institutions: Heidelberg Institute for Theoretical Studies (HITS gGmbH)
https://orcid.org/0000-0002-4980-3512
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Institutions: Vall d´Hebron Institute of Oncology (VHIO)
Projects: MESI-STRAT
Institutions: German Cancer Research Center (DKFZ)
https://orcid.org/0000-0002-9659-9825
Projects: MESI-STRAT
Institutions: University of Groningen
Projects: MESI-STRAT
Institutions: Charité University Medicine Berlin
Contributor: Pamela Riemer
Provider Name: Opitz lab
Provider's strain ID: MCF-7
Organism: Homo sapiens
Genotypes: wild-type
Phenotypes: wild-type
Comment: The cells were sent to CHAB from Opitz lab and STR profiled to confirm their identity. Their mutational pattern was analysed by panel DNA sequencing as described in file "MESI-STRATcells.docx".
Abstract (Expand)
Authors: A. K. Stavrum, Ines Heiland, S. Schuster, P. Puntervoll, Mathias Ziegler
Date Published: No date defined
Journal: J Biol Chem
Abstract (Expand)
Authors: D. L. Dewi, S. R. Mohapatra, S. Blanco Cabanes, I. Adam, L. F. Somarribas Patterson, B. Berdel, M. Kahloon, L. Thurmann, S. Loth, K. Heilmann, D. Weichenhan, O. Mucke, Ines Heiland, P. Wimberger, J. D. Kuhlmann, Karl-Heinz Kellner, Sarah Schott, C. Plass, M. Platten, C. Gerhauser, S. Trump, Christiane Opitz
Date Published: No date defined
Journal: Oncoimmunology
Abstract (Expand)
Authors: I. Johansson, C. Nilsson, P. Berglund, M. Lauss, M. Ringner, H. Olsson, L. Luts, E. Sim, S. Thorstensson, M. L. Fjallskog, I. Hedenfalk
Date Published: No date defined
Journal: Breast Cancer Res
Abstract (Expand)
Authors: H. D. Biesma, P. C. Schouten, M. M. Lacle, J. Sanders, W. Brugman, R. Kerkhoven, I. Mandjes, P. van der Groep, P. J. van Diest, S. C. Linn
Date Published: No date defined
Journal: Genes Chromosomes Cancer
