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MESI-STRAT: Systems Medicine of Metabolic-Signaling Networks -A New Concept for Breast Cancer Patient Stratification.
Breast cancer is a complex disease with high prevalence in the European Union and world-wide. 75%-80 of the patients have estrogen receptor-positive (ER)-positive tumors and are treated with endocrine therapies. Endocrine therapies, which block ER-driven tumor growth, show high efficacy. Yet, a significant proportion of the patients will eventually relapse with metastatic breast cancer, and the recurrence rates remain almost constant for up to 20 years. MESI-STRAT develops metabolite marker panels measurable in biological fluids to enable patient stratification, resistance monitoring and clinical decision-making throughout endocrine therapy. This is a new concept as breast cancer metabolism is poorly explored for diagnostics and therapy. Upon successful validation in preclinical models, the predictive marker panels and related treatments will be jointly investigated by MESI-STRAT’s clinical and industrial partners. The MESI-STRAT consortium explores the interplay of breast cancer metabolism and oncogenic signaling (MEtabolic SIgnaling) by systems medicine approaches. MESI-STRAT develops new models for knowledge-based STRATification of patients into subgroups with different endocrine therapy resistance mechanisms.
Programme: This Project is not associated with a Programme
SEEK ID: https://fairdomhub.org/projects/99
Public web page: http://www.mesi-strat.eu
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus
FAIRDOM PALs: No PALs for this Project
Project created: 26th Feb 2018
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Projects: MESI-STRAT
Institutions: PATH - Patients' Tumor Bank of Hope
Projects: SilicoTryp, Multiscale modelling of state transitions in the host-microbiome-brain network, MESI-STRAT, PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: University of Groningen
I am an Associate Professor in Systems Biology and the University Medical Centre Groningen. My research aims at understanding how energy metabolism is integrated and regulated. My work includes experimental, modelling as well as theoretical research. Recently I studied how metabolic regulation and gene-expression regulation work together towards in integrated response, e.g. when parasites are confronted with chemical inhibitors. Much of my work has been about the regulation of glycolysis and its
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Projects: MESI-STRAT
Institutions: German Cancer Research Center (DKFZ)
Projects: MESI-STRAT
Institutions: Charité University Medicine Berlin
Projects: MESI-STRAT
Institutions: Durham University
Expertise: RNA, alternative splicing, Bioinformatics, Genomics
Projects: MESI-STRAT
Institutions: University of Groningen
Projects: MESI-STRAT
Institutions: University of Groningen
Projects: MESI-STRAT
Institutions: The Arctic University of Norway (UiT)
Projects: MESI-STRAT
Institutions: Neuroimmun GmbH
Projects: SysMO DB, FAIRDOM, ICYSB 2015 - International Practical Course in Systems Biology, ZucAt, SysMO-LAB, Kinetics on the move - Workshop 2016, Example use cases, FAIRDOM user meeting, ErasysApp Funders, EraCoBiotech 2 nd call proposal preparation, Service to URV Tarragona, Spain with respect to their Safety Assessment of Endocrine Disrupting Chemicals model (Active NOW), FAIRDOM & LiSyM & de.NBI Data Structuring Training, MESI-STRAT, INCOME, Multiscale modelling of state transitions in the host-microbiome-brain network, BESTER, TRALAMINOL, Sustainable co-production, INDIE - Biotechnological production of sustainable indole, Extremophiles metabolsim, PoLiMeR - Polymers in the Liver: Metabolism and Regulation, GB-XMap: Assessing the risk of gut-brain cross-diseases Investigating the gut-brain-axis
Institutions: Heidelberg Institute for Theoretical Studies (HITS gGmbH), FAIRDOM User meeting, Norwegian University of Science and Technology

Expertise: semantics, data modelling, curation, ontology, Transcriptomics, Data Management, Bioinformatics, Molecular Biology, Genetics
Tools: RightField, Protege, seek, BioMart, Chip-chip, Databases, Cell and tissue culture
I am a researcher at the Scientific Databases and Visualization Group at Heidelberg Institute for Theoretical Studies (HITS) , one of the developers of SabioRK - System for the Analysis of Biochemical Pathways - Reaction Kinetics (http://sabiork.h-its.org/) . I am working on design and maintenance of the information systems to store, query and analyse systems biology data; definition and implementation of methods for the integration of data from multiple sources. In SySMO-DB project
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Abstract (Expand)
Authors: Ines Heiland, Mathias Ziegler, Stavrum A. K.,Schuster S.,Puntervoll P.
Date Published: No date defined
Journal: J Biol Chem
PubMed ID: 24129579
Citation: J Biol Chem. 2013 Nov 29;288(48):34555-66. doi: 10.1074/jbc.M113.474908. Epub 2013 Oct 15.
Abstract (Expand)
Authors: Ines Heiland, Karl-Heinz Kellner, Sarah Schott, Christiane Opitz, Dewi D. L.,Mohapatra S. R.,Blanco Cabanes S.,Adam I.,Somarribas Patterson L. F.,Berdel B.,Kahloon M.,Thurmann L.,Loth S.,Heilmann K.,Weichenhan D.,Mucke O.,Wimberger P.,Kuhlmann J. D.,Plass C.,Platten M.,Gerhauser C.,Trump S.
Date Published: No date defined
Journal: Oncoimmunology
PubMed ID: 28344890
Citation: Oncoimmunology. 2017 Jan 3;6(2):e1274477. doi: 10.1080/2162402X.2016.1274477. eCollection 2017.
Abstract (Expand)
Author: Johansson I.,Nilsson C.,Berglund P.,Lauss M.,Ringner M.,Olsson H.,Luts L.,Sim E.,Thorstensson S.,Fjallskog M. L.,Hedenfalk I.
Date Published: No date defined
Journal: Breast Cancer Res
PubMed ID: 22333393
Citation: Breast Cancer Res. 2012 Feb 14;14(1):R31. doi: 10.1186/bcr3116.
Abstract (Expand)
Author: Biesma H. D.,Schouten P. C.,Lacle M. M.,Sanders J.,Brugman W.,Kerkhoven R.,Mandjes I.,van der Groep P.,van Diest P. J.,Linn S. C.
Date Published: No date defined
Journal: Genes Chromosomes Cancer
PubMed ID: 26355282
Citation: Genes Chromosomes Cancer. 2015 Dec;54(12):734-44. doi: 10.1002/gcc.22284. Epub 2015 Sep 10.