Sustained glycolytic oscillations in individual isolated yeast cells - II
Version 5

LightningSimulate Model on JWS BuildDownload

Using optical tweezers to position yeast cells in a microfluidic chamber, we were able to observe sustained oscillations in individual isolated cells. Using a detailed kinetic model for the cellular reactions, we simulated the heterogeneity in the response of the individual cells, assuming small differences in a single internal parameter. By operating at two different flow rates per experiment, we observe four of categories of cell behaviour. The present model (gustavsson2) predicts the damped oscillation to limit cycle transition observed in 13.6% of the cell population.


1 item is associated with this Model:
  • gustavsson2.dat (uuencoded file - 11.6 KB) Download

Organism: Saccharomyces cerevisiae

Model type: Ordinary differential equations (ODE)

Model format: Not specified

Execution or visualisation environment: JWS Online

Model image: No image specified

help Contributor and Creators

help Other creators

David D van Niekerk
No license specified

Views: 1793   Downloads: 106

Created: 23rd Jul 2012 at 23:34

Last updated: 23rd Jul 2012 at 01:51

Last used: 23rd Jan 2018 at 17:07

help Attributions


Related items

Powered by
Seek new full
Copyright © 2008 - 2018 The University of Manchester and HITS gGmbH