Sustained glycolytic oscillations in individual isolated yeast cells - III

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Using optical tweezers to position yeast cells in a microfluidic chamber, we were able to observe sustained oscillations in individual isolated cells. Using a detailed kinetic model for the cellular reactions, we simulated the heterogeneity in the response of the individual cells, assuming small differences in a single internal parameter. By operating at two different flow rates per experiment, we observe four of categories of cell behaviour. The present model (gustavsson3) predicts the steady-state to limit cycle transition observed in 40.2% of the cell population.

FAIRDOMHub ID: https://seek.sysmo-db.org/models/82?version=3

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  • gustavsson3.dat (uuencoded file - 11.4 KB) Download

Organism: Saccharomyces cerevisiae

Model type: Ordinary differential equations (ODE)

Model format: Not specified

Execution or visualisation environment: JWS Online

Model image: No image specified

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David D van Niekerk
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Views: 1519   Downloads: 97

Created: 23rd Jul 2012 at 23:24

Last updated: 23rd Jul 2012 at 01:49

Last used: 22nd Sep 2017 at 05:06

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