We used parameter scanning to emulate changes to the limiting rate for steps in a fitted model of glucose-derepressed yeast glycolysis. Three flux-control regimes were observed, two of which were under the dominant control of hexose transport, in accordance with various experimental studies and other model predictions. A third control regime in which phosphofructokinase exerted dominant glycolytic flux control was also found, but it appeared to be physiologically unreachable by this model, and all realistically obtainable flux control regimes featured hexose transport as a step involving high flux control.
PubMed ID: 12180966
Projects: Example use cases
Journal: Eur J Biochem
Citation: Eur J Biochem. 2002 Aug;269(16):3894-904.
Date Published: No date defined
Authors: L. Pritchard, D. B. Kell
Created: 11th Apr 2018 at 13:50