Projects: TRANSLUCENT
Institutions: University of Cordoba
Professor of Microbiology
Projects: COSMIC
Institutions: University of Nottingham
Expertise: Synthetic Biology, Systems Biology, Molecular Biology, Genetics, Microbiology
Tools: Genetic analysis, Genetic modification
I'm an 'experimentalist' (molecular microbiologist) Postdoc working on regulation and peptide signaling in Clostridium acetobutylicum.
I'm also a SysMO-DB PAL (Product Application Liason) for COSMIC, working on data management including standards and integration with SysMO SEEK.
Projects: BaCell-SysMO
Institutions: University of Groningen
Expertise: Systems Biology, regulation of gene expression, Signal transduction in Gram-negative bacteria; Synthetic Microbiology; Single cell gene expression; Regulatory networks; biochemistry; histidine ki..., gene regulation, stress responses, sporulation, phenotypic heterogeneity, bistability, translational control of gene expression, Bacillus subtilis, Molecular Biology, Genetics, Microbiology
Tools: Time-lapse fluorescence microscopy Flow cytometry, Molecular biology techniques (RNA/DNA), time lapse microscopy, Fluorecence based reporter gene analyses/single cell analyses, PCR, Model organisms, Single Cell analysis, Genetic analysis, Genetic modification, Molecular Biology, Genetics, Microbiology
Projects: BaCell-SysMO
Institutions: University of Goettingen
Expertise: protein-protein interactions, Mycoplasma pneumoniae, Cell physiology, protein-RNA interactions, regulation of gene expression, Bacillus subtilis, Molecular Biology, Genetics, Microbiology
Tools: SubtiWiki, SPINE, bacterial two-hybrid system, Chemical cross-linking, Proteomics (2D-PAGE), mutant strain generation, Genetic analysis, Genetic modification, Biochemistry and protein analysis, Molecular Biology, Microbiology
Projects: BaCell-SysMO
Institutions: University of Newcastle
Expertise: Genetics), Systems Biology, Gram positive bacteria (Bacillus, Molecular Biology, Microbiology
Tools: molecular biological techniques (RNA/DNA techniques), protein interaction studies, DNA technology RNA technology Protein analysis Fermentation Mutagenesis, gene regulation, Proteomics (2D-PAGE), Model organisms, Proteomics, Transcriptomics, Genetic analysis, Genomics, Cell biology, Biochemistry and protein analysis, Molecular Biology, Microbiology
Optimisation of Bacillus subtilis for the secretion of heterologous proteins Therapeutic proteins (including those required for experimental purposes and clinical trials) are major products of biomanufacturing processes and considerable time and expense are expended to maximise the yield and quality of proteins produced in heterologous hosts. The production host of choice is the Gram-negative bacterium Escherichia coli for which many strains and expression systems have been developed. However,
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