Projects

Real-time smart monitoring of bioprocesses for efficient conversion of organic carbon to volatile fatty acids

Hypoglycaemia and lactic acidosis are key diagnostics for poor chances of survival in malaria patients. In this project we aim to test to what extent the metabolic activity of Plasmodium falciparum contributes to a changed glucose metabolism in malaria patients. The approach is to start with detailed bottom up models for the parasite and then merge these with more coarse grained models at the whole body level.

GMO free systems optimization of wine yeast for wine production by massive scale directed evolution

The group around Nicole Radde specializes in the modeling, analysis, and simulation of biochemical systems. This especially includes parameter optimization and identification.

LEADER: StU (prof. B. Klumperman)

PARTNERS: StU & SU

OBJECTIVES:

• Optimization of antimalarial drug encapsulation for fast release.

• Development of transmission blocking drug encapsulation for slow release.

DELIVERABLES:

**07.2022 D ...

LEADER: IPF (prof. A. Lederer)

PARTNERS: IPF & StU

OBJECTIVES:

• Determination of stability, degradation and drug release kinetics.

• Mathematical modelling of response to treatments of infectious diseases.

DELIVERABLES

10.2022 M 3.1 ...

LEADER: prof. L-M. Birkholtz

PARTNERS: UP & WITS & SU & StU

OBJECTIVES:

• Evaluation of the ability of the novel polymer-drug systems to kill the transmissible gametocytes.

• Validation using treatment of anopheline mosquitoes in a membrane feeding assay.

...

LEADER: UL (prof. J.C. Simon)

PARTNERS: UL & IPF & SU & StU

OBJECTIVES:

• Validation of biocompatibility of the drug delivery systems with the skin.

• Testing of the drug delivery into and through the skin.

DELIVERABLES ...

WURSynBio