Projects

What is a Project?
385 Projects found

In this project, we integrate COVID19 Disease Maps curated regulatory information in a macrophage logical model. This allows logical simulations of the effects of acute inflammation caused by the SARS-CoV-2 virus, both in general and in a cell-specific perspective. Moreover, understanding the regulatory network behavior of macrophages following infection opens new ways to test and predict drug and drug combination effects, as a first step towards the development of new treatments.

Programme: Macrophage logical modeling

Public web page: Not specified

Start date: 1st Oct 2020

We used the Neo4j graph database approach to integrate the content of the COVID-19 Disease Map diagrams to efficiently access, query and manage the content of these diagrams and enable communication with external resources, such as Reactome and Recon, that already provide support via a similar environment. This work complements the efforts on exploring COVID-19 disease mechanisms within the COVID-19 Disease Map Project.

Programme: C19DM-Neo4j

Public web page: Not specified

Start date: 1st Sep 2020

End date: 31st Dec 2022

ERACoBioTech project

Programme: Era CoBioTech

Public web page: https://www.ntnu.edu/c1pro

Further proteomic data and ATP calculation

Programme: BaPro

Public web page: Not specified

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Programme: Druglogics

Public web page: Not specified

As an Innovative Training Network (ITN) , our approach to bringing about innovation is via education. The 15 Early Stage Researchers that join our project will gain multidisciplinary and cutting-edge expertise from our hosting institutions and associated partners, which is required to manipulate biological catalysts for meeting tomorrow’s demanding challenges in sustainable production processes.

CC-TOP is focused on exploiting the potential benefits of C-C bond forming enzymes (“carboligases”) ...

Programme: EU Projects

Public web page: https://cc-top-itn.eu/

Start date: 1st Mar 2021

End date: 30th Mar 2024

No description specified

Programme: Era CoBioTech

Public web page: https://www.ufz.de/cell4chem/

Start date: 1st Jul 2021

End date: 30th Jun 2024

CEPOPA envisions a sustainable cascade one-pot process for the synthesis of optically pure amines from alcohols and/or alkynes, using enzymes immobilized onto catalytically active nanomaterials. In the framework of the project, efficient chemoenzymatic processes will be developed for the synthesis of a set of amines that can be used as building blocks for pharmaceuticals or biomaterials.

Programme: Hellenic Foundation for Research and Innovation - Supporting academic Staff and Researchers

Public web page: Not specified

Start date: 24th Feb 2020

End date: 23rd Aug 2023

No description specified

Programme: RNA Systems Biology Lab

Public web page: Not specified

No description specified

Programme: DiaPhotosynth

Public web page: Not specified

Start date: 3rd Feb 2020

End date: 31st Aug 2023

The project brings comprehensive study of diversity in Clostridium beijerinckii, solvent-producing species with potential use in industrial biotechnology.

Programme: Clostridium beijerinckii

Public web page: Not specified

Storage of thermophysical properties (e.g. density, viscosity, thermodynamic activity of water, conductivity) using Chemical Markup Language (CML).

Programme: This Project is not associated with a Programme

Public web page: Not specified

Collection of coastal data via telemetry and sensors

Programme: Independent Projects

Public web page: https://www.afbini.gov.uk

The COLOSYS project aims to develop a deeper understanding of colon cancer networks and convert them into computer models with which it will be better to predict response to treatment. The combination of computational, experimental and clinical testing will provide understanding of drug resistance mechanisms, and allow personalised treatment of colon cancer.

Programme: Druglogics

Public web page: http://www.colosys.org/

No description specified

Placental dysfunction has been associated with various pregnancy complications leading to both maternal and fetal death and long-term consequences, however, the placenta is one of the least studied organs within the human body. In this pilot study, protein signature of three healthy placentae was measured using label free quantification mass spectrometry. Each placenta was sampled in five sample sites and three sub-anatomical regions. Differentially expressed proteins were identified considering ...

The goal of the project is to establish a new biotechnological platform for the production of hydroxy-amino acids, since the current production of these important building blocks is very expensive. Enzyme engineering, systems biotechnology and metabolic engineering will be used in a synthetic biology approach.

Programme: SARCHI: Mechanistic modelling of health and epidemiology

Public web page: Not specified

Data and experimental methods to support the work in the following paper:

Establishing Consensus Annotation for the Hallmarks of Cancer, 2020, Yi Chen, F.J.Verbeek and K.Wolstencroft, in submission

Programme: Hallmarks of cancer

Public web page: Not specified

Cell biological and proteogenomic study of the chloroplast of the marine, bloom-forming dinoflagellate P. cordatum

Programme: Independent Projects

Public web page: Not specified

Start date: 4th Jul 2023

End date: 31st Aug 2024

Increasing temperature in the European wine producing regions is having a negative impact on this key sector. Climate change results in a lack of balance between technological and phenolic ripening of wine grapes and, as a consequence, alcohol increase in wines. This trend is of great concern for the European wine industry because it has a negative impact on wine quality, becomes a hurdle for international trade, and jeopardizes compatibility of moderate wine consumption with a healthy lifestyle. ...

Programme: CoolWine

Public web page: Not specified

Systems Biology of Clostridium acetobutylicum - a possible answer to dwindling crude oil reserves

Here we share resources and best practices to develop a disease map for COVID-19. The project is progressing as a broad community-driven effort. We aim to establish a knowledge repository on virus-host interaction mechanisms specific to the SARS-CoV-2. The COVID-19 Disease Map is an assembly of molecular interaction diagrams established based on literature evidence.

This project bundles information about COVID-19 related studies and tools in Germany. It intends to provide an information hub for the different initiatives, their aims, their processes, standards and study protocols, as well as their available data and metadata. It is initiated by the German National Research Data Infrastructure for Personal Health Data (nfdi4health), a consortium that plans to establish a concept for a federated research data infrastructure for personal health data in Germany. ...

In the CoVIDD project, we aim at unravelling interactions of viral proteins with the cellular factors and the host pathways involved in SARS-CoV-2 infection by a combination of modern technologies, genomics, proteomics, structural biology, chemoinformatics and drug discovery. To effectively search for drugs that could modify viral replication we need to know what human proteins and viral proteins interact. Thus, a comprehensive virus-host protein interaction network will help us to identify the ...

Programme: This Project is not associated with a Programme

Public web page: Not specified

CropClock - Increasing Crops Biomass by Uncovering the Circadian Clock Network Using Dynamical Models

The circadian clock is an internal timing system that allows plants to predict daily and seasonal changes in light and temperature and thus to adapt photosynthesis, growth, and development to external conditions. The core oscillator is well understood in the model plant Arabidopsis, however, relatively little is known about the dynamic effects of the clock on agronomic behaviour of crop plants. ...

Programme: ERASysAPP

Public web page: Not specified

In the project “Crossover Research 2.0 – Well constructed Knowledge Commons” the domain of precision medicine is explored as a key visionary driver for developing the Knowledge Commons and the enabling of Systems Biology approaches to innovate healthcare. In particular, we seek to engage stakeholder concerns in investigating and establishing strategies for DrugLogics to contribute to the Knowledge Commons in an RRI mode.

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