Iterative cycles of model improvement and extension.

The output of the initial model of redox metabolism will be compared to experimental flux and metabolite data. Deviations between model and experiment will be prioritized together with WP2. We will apply Metabolic Control
Analysis (Fell 1992 PMID: 1530563) to diagnose which enzymes control the deviating metabolite
concentrations and/or rates. When the agreement between model and experiment is sufficient
we will first link it to the existing model of trypanosome glycolysis and repeat the same quality control procedure. Further extensions of the
network will be prioritized based experimental data analyses coming from WP1


Dynamic modelling of redox metabolism and gene expression

Projects: SilicoTryp

Jurgen Haanstra

Experimentalists: Jurgen Haanstra, Federico Rojas

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Views: 912

Created: 29th Feb 2012 at 08:55

Last updated: 29th Feb 2012 at 11:13

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