Figure 4C: Biphasic control can provide mutant resistance to stem-cell homeostatic circuits.

C A mutated stem cell with a strong inactivation of the sensing of y has a
growth advantage (differentiates less), and therefore, it invades the stem- cell population. As a result, both the stem-cell pool and the number of terminally differentiated cells increase.

SED-ML simulation
https://jjj.bio.vu.nl/models/experiments/karin2017_fig4c/simulate

SEEK ID: https://fairdomhub.org/studies/388

Karin et al (2017) Molecular Systems Biology

Projects: Molecular Systems Biology

Jacky Snoep

Experimentalists: Not specified

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Created: 31st Jul 2018 at 12:24

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