I am pursuing my PhD at Prof. Volker's Lab in the Department of Functional Genomics, EMA Universitat Greifswald, Germany. I am working on the general stress responses mediated by SigB and the prediction of SigB regulon members using the Random forest algorithm.
Modelling carbon core metabolism in Bacillus subtilis – Exploring the contribution of protein complexes in core carbon and nitrogen metabolism.
Bacillus subtilis is a prime model organism for systems biology approaches because it is one of the most advanced models for functional genomics. Furthermore, comprehensive information on cell and molecular biology, physiology and genetics is available and the European Bacillus community (BACELL) has a well-established reputation for applying
Recent studies revealed the unsuspected complexity of the bacterial transcriptome but its systematic analysis across many diverse conditions remains a challenge. Here we report the condition-dependent transcriptome of the prototype strain B. subtilis 168 across 104 conditions reflecting the bacterium's life-styles. This data set composed of 269 tiling array hybridizations allowed to observe ~85% of the annotated CDSs expressed in the higher 30% in at least one hybridization and thus provide an
Contributor: Leif Steil
Investigations: Redefining the Complete Transcriptome of Bacill...
Authors: Pierre Nicolas, Ulrike Mäder, Etienne Dervyn, Tatiana Rochat, Aurélie Leduc, Nathalie Pigeonneau, Elena Bidnenko, Elodie Marchadier, Mark Hoebeke, Stéphane Aymerich, Dörte Becher, Paola Bisicchia, Eric Botella, Olivier Delumeau, Geoff Doherty, Emma L Denham, Mark J Fogg, Vincent Fromion, Anne Goelzer, Annette Hansen, Elisabeth Härtig, Colin Harwood, Georg Homuth, Hanne Jarmer, Matthieu Jules, Edda Klipp, Ludovic Le Chat, François Lecointe, Rick Lewis, Wolfram Liebermeister, Anika March, Ruben Mars, Priyanka Nannapaneni, David Noone, Susanne Pohl, Bernd Rinn, Frank Rügheimer, Praveen Kumar Sappa, Franck Samson, Marc Schaffer, Benno Schwikowski, Leif Steil, Joerg Stuelke, Thomas Wiegert, Kevin M Devine, Anthony J Wilkinson, Jan Maarten Van Dijl, Michael Hecker, Uwe Voelker, Philippe Bessières, Philippe Noirot
Date Published: 3rd Mar 2012
PubMed ID: 22383849