Transcriptional response to a sudden increase in extracellular ligand (hormone), for the six network designs of (A). The transcriptional response is taken to equal the ratio ReNrL/Retotal, i.e., the fraction of REs attaching ligand-bound NR. The ligand concentration was increased from 0 to 0.005 nM and maintained constant at the latter level. The observation that design 6 is higher than all other designs at long times is robust for parameter changes up to a factor of 3.
FAIRDOMHub ID: https://seek.sysmo-db.org/studies/151
Projects: Molecular Systems Biology
Experimentalists: Not specified
Created: 17th May 2016 at 14:13
Disciplines: Not specified
Roles: Not specified
Expertise: Not specified
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Design principles of nuclear receptor signaling: how complex networking improves signal transduction
SED-ML simulation: https://jjj.bio.vu.nl/models/experiments/bachmann2011/simulate
Contributor: Dawie Van Niekerk
Biological problem addressed: Modelling Analysis
Investigation: Kolodkin et al (2010) Molecular Systems Biology...