Modeling of cellular processes: methods, data, and requirements


Systems biology is a comprehensive quantitative analysis how the components of a biological system interact over time which requires an interdisciplinary team of investigators. System-theoretic methods are applied to investigate the system's behavior. Using known information about the considered system, a conceptual model is defined. It is transferred in a mathematical model that can be simulated (analytically or numerically) and analyzed using system-theoretic tools. Finally, simulation results are compared with experimental data. However, assumptions, approximations, and requirements to available experimental data are crucial ingredients of this systems biology workflow. Consequently, the modeling of cellular processes creates special demands on the design of experiments: the quality, the amount, and the completeness of data. The relation between models and data is discussed in this chapter. Thereby, we focus on the requirements on experimental data from the perspective of systems biology projects.


PubMed ID: 21063964

Projects: BaCell-SysMO, COSMIC

Journal: Methods Mol. Biol.


Date Published: 11th Nov 2010

Author: Not specified

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Views: 3432

Created: 20th Jan 2011 at 14:40

Last updated: 20th Jan 2011 at 14:40

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