Systems biology: the elements and principles of life


Systems Biology has a mission that puts it at odds with traditional paradigms of physics and molecular biology, such as the simplicity requested by Occam's razor and minimum energy/maximal efficiency. By referring to biochemical experiments on control and regulation, and on flux balancing in yeast, we show that these paradigms are inapt. Systems Biology does not quite converge with biology either: Although it certainly requires accurate 'stamp collecting', it discovers quantitative laws. Systems Biology is a science of its own, discovering own fundamental principles, some of which we identify here.


PubMed ID: 19913018

Projects: MOSES

Journal: FEBS Lett.


Date Published: 6th Nov 2009

Authors: Hans Westerhoff, Catherine Winder, Hanan Messiha, Evangelos Simeonidis, Malgorzata Adamczyk, Malkhey Verma, Frank J Bruggeman, Warwick Dunn

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Views: 2913

Created: 6th Jun 2010 at 17:51

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