The PII protein GlnK is a pleiotropic regulator for morphological differentiation and secondary metabolism in Streptomyces coelicolor

Abstract:

GlnK is an important nitrogen sensor protein in Streptomyces coelicolor. Deletion of glnK results in a medium-dependent failure of aerial mycelium and spore formation and loss of antibiotic production. Thus, GlnK is not only a regulator of nitrogen metabolism but also of morphological differentiation and secondary metabolite production. Through a comparative transcriptomic approach between the S. coelicolor wild-type and a S. coelicolor glnK mutant strain, 142 genes were identified that are differentially regulated in both strains. Among these are genes of the ram and rag operon, which are involved in S. coelicolor morphogenesis, as well as genes involved in gas vesicle biosynthesis and ectoine biosynthesis. Surprisingly, no relevant nitrogen genes were found to be differentially regulated, revealing that GlnK is not an important nitrogen sensor under the tested conditions.

SEEK ID: https://fairdomhub.org/publications/296

PubMed ID: 22033567

Projects: STREAM

Journal: Appl Microbiol Biotechnol

Citation: Appl Microbiol Biotechnol. 2011 Dec;92(6):1219-36. doi: 10.1007/s00253-011-3644-1. Epub 2011 Oct 28.

Date Published: 29th Oct 2011

Authors: E. Waldvogel, A. Herbig, F. Battke, R. Amin, M. Nentwich, K. Nieselt, T. E. Ellingsen, A. Wentzel, D. A. Hodgson, W. Wohlleben, Y. Mast

Help
help Creator
Activity

Views: 2537

Created: 3rd Dec 2016 at 20:45

help Attributions

None

Related items

Powered by
(v.1.9.0)
Copyright © 2008 - 2019 The University of Manchester and HITS gGmbH