Quantitative analysis of drug effects at the whole-body level: a case study for glucose metabolism in malaria patients

Abstract:

We propose a hierarchical modelling approach to construct models for disease states at the whole-body level. Such models can simulate effects of drug-induced inhibition of reaction steps on the whole-body physiology. We illustrate the approach for glucose metabolism in malaria patients, by merging two detailed kinetic models for glucose metabolism in the parasite Plasmodium falciparum and the human red blood cell with a coarse-grained model for whole-body glucose metabolism. In addition we use a genome-scale metabolic model for the parasite to predict amino acid production profiles by the malaria parasite that can be used as a complex biomarker.

Citation: Biochemical Society Transactions 43(6) : 1157

Date Published: 27th Nov 2015

Authors: Jacky Snoep, Kathleen Green, J. Eicher, D. C. Palm, G. Penkler, F. du Toit, N. Walters, R. Burger, H. V. Westerhoff, Dawie Van Niekerk

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Snoep, J. L., Green, K., Eicher, J., Palm, D. C., Penkler, G., du Toit, F., … van Niekerk, D. D. (2015). Quantitative analysis of drug effects at the whole-body level: a case study for glucose metabolism in malaria patients. Biochemical Society Transactions, 43(6), 1157–1163. http://doi.org/10.1042/bst20150145
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Created: 30th Aug 2016 at 15:09

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