Modeling the cell division cycle: cdc2 and cyclin interactions

Abstract:

The proteins cdc2 and cyclin form a heterodimer (maturation promoting factor) that controls the major events of the cell cycle. A mathematical model for the interactions of cdc2 and cyclin is constructed. Simulation and analysis of the model show that the control system can operate in three modes: as a steady state with high maturation promoting factor activity, as a spontaneous oscillator, or as an excitable switch. We associate the steady state with metaphase arrest in unfertilized eggs, the spontaneous oscillations with rapid division cycles in early embryos, and the excitable switch with growth-controlled division cycles typical of nonembryonic cells.

SEEK ID: https://fairdomhub.org/publications/251

PubMed ID: 1831270

Projects: Kinetics on the move - Workshop 2016

Journal: Proc Natl Acad Sci U S A

Citation: Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7328-32.

Date Published: 15th Aug 1991

Author: J. J. Tyson

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