Evolution, dynamics and specialized functions of glycosomes in metabolism and development of trypanosomatids

Abstract:

Kinetoplastea such as trypanosomatid parasites contain specialized peroxisomes that uniquely contain enzymes of the glycolytic pathway and other parts of intermediary metabolism and hence are called glycosomes. Their specific enzyme content can vary strongly, quantitatively and qualitatively, between different species and during the parasites’ life cycle. The correct sequestering of enzymes has great importance for the regulation of the trypanosomatids’ metabolism and can, dependent on environmental conditions, even be essential. Glycosomes also play a pivotal role in life-cycle regulation of Trypanosoma brucei, as the translocation of a protein phosphatase from the cytosol forms part of a crucial developmental control switch. Many glycosomal proteins are differentially phosphorylated in different life-cycle stages, possibly indicative for unique forms of activity regulation, whereas many kinetic activity regulation mechanisms common for glycolytic enzymes are absent in these organisms. Glycosome turnover occurs by autophagic degradation of redundant organelles and assembly of new ones. This may provide the trypanosomatids with a manner to rapidly and efficiently adapt their metabolism to the sudden, major nutritional changes often encountered during the life cycle. This could also have helped facilitating successful adaptation of kinetoplastids, at multiple occasions during evolution, to their parasitic life style.

SEEK ID: https://fairdomhub.org/publications/233

DOI: 10.1016/j.mib.2014.09.006

Projects: SilicoTryp

Journal: Current Opinion in Microbiology

Citation:

Date Published: 1st Dec 2014

Authors: Balázs Szöör, Jurgen Haanstra, Melisa Gualdrón-López, Paul AM Michels

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Szöör, B., Haanstra, J. R., Gualdrón-López, M., & Michels, P. A. M. (2014). Evolution, dynamics and specialized functions of glycosomes in metabolism and development of trypanosomatids. Current Opinion in Microbiology, 22, 79–87. http://doi.org/10.1016/j.mib.2014.09.006
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Created: 3rd Nov 2014 at 16:21

Last updated: 3rd Nov 2014 at 16:22

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