Functional genomics of the initial phase of cold adaptation of Pseudomonas putida KT2440
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BiBTeXThe cold stress response of Pseudomonas putida KT2440 was investigated by genomewide deep cDNA sequencing and gel-free MS-based protein profiling. Transcriptome and proteome profiles were assessed at 30 degrees C and 2 h after a downshift from 30 to 10 degrees C. Pseudomonas putida adapted to lower ambient temperature by the activation of ribosome-associated functional modules that facilitate translational efficiency. The outer membrane profile was reorganized, anabolic pathways and core as well as energy metabolism were repressed and the alginate regulon and sugar catabolism were activated. At the investigated early time point of cold adaptation, the transcriptome was reprogrammed in almost all functional categories, but the protein profile had still not adapted to the change of living conditions in the cold.
SEEK ID: https://fairdomhub.org/publications/222
PubMed ID: 21306427
Projects: PSYSMO
Publication type: Not specified
Journal: FEMS Microbiol Lett
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Date Published: 1st Mar 2011
Registered Mode: Not specified
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Created: 23rd Jun 2014 at 14:15
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Projects: PSYSMO
Institutions: University of Hannover
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Institutions: University of Hannover
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Institutions: Helmholtz Centre for Infection Research Braunschweig
I am an engineer with a PhD degree in Chemical Engineering and had been working on dynamic modeling of mammalian cell culture fermentation in London for three years before moving into simulation of microbial systems. In this PSYSMO project I am mainly involved in modeling of PHAs synthesis. I am also a PAL since May 2009 - 2011 to coordinate data management and general communication among all 17 partners.
Projects: PSYSMO
Institutions: University of Hannover
SysMO is a European transnational funding and research initiative on "Systems Biology of Microorganisms".
The goal pursued by SysMO was to record and describe the dynamic molecular processes going on in unicellular microorganisms in a comprehensive way and to present these processes in the form of computerized mathematical models.
Systems biology will raise biomedical and biotechnological research to a new quality level and contribute markedly to progress in understanding. Pooling European research ...
Projects: BaCell-SysMO, COSMIC, SUMO, KOSMOBAC, SysMO-LAB, PSYSMO, SCaRAB, MOSES, TRANSLUCENT, STREAM, SulfoSys, SysMO DB, SysMO Funders, SilicoTryp, Noisy-Strep
Web page: http://sysmo.net/
Systems analysis of process-induced stresses: towards a quantum increase in process performance of Pseudomonas putida as the cell factory of choice for white biotechnology.
The specific goal of this project is to exploit the full biotechnological efficacy of Pseudomonas putida KT2440 by developing new optimization strategies that increase its performance through a systems biology understanding of key metabolic and regulatory parameters that control callular responses to key stresses generated ...
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Public web page: http://www.psysmo.org/
