Publications

Abstract (Expand)

For adaptation between anaerobic, micro-aerobic and aerobic conditions Escherichia coli's metabolism and in particular its electron transport chain (ETC) is highly regulated. Although it is known ...

Authors: None

Date Published: 30th Sep 2014

Journal: PLoS One

Abstract (Expand)

Escherichia coli is a facultatively anaerobic bacterium. With glucose if no external electron acceptors are available, ATP is produced by substrate level phosphorylation. The intracellular redox balance ...

Authors: Katja Bettenbrock, Hao Bai, Michael Ederer, Jeff Green, Klaas Hellingwerf, Michael Holcombe, S. Kunz, Matthew Rolfe, Guido Sanguinetti, Oliver Sawodny, Poonam Sharma, Sonja Steinsiek, Robert Poole

Date Published: 7th May 2014

Journal: Adv Microb Physiol

Abstract (Expand)

In the presence of oxygen (O2) the model bacterium Escherichia coli is able to conserve energy by aerobic respiration. Two major terminal oxidases are involved in this process - Cyo has a relatively ...

Authors: Hao Bai, Matthew Rolfe, Wenjing Jia, S. Coakley, Robert Poole, Jeff Green, Michael Holcombe

Date Published: 24th Apr 2014

Journal: PLoS Comput Biol

Abstract (Expand)

The efficient redesign of bacteria for biotechnological purposes, such as biofuel production, waste disposal or specific biocatalytic functions, requires a quantitative systems-level understanding of ...

Authors: None

Date Published: 27th Mar 2014

Journal: Front Microbiol

Abstract (Expand)

The respiratory chain of E. coli is branched to allow the cells' flexibility to deal with changing environmental conditions. It consists of the NADH:ubiquinone oxidoreductases NADH dehydrogenase I ...

Authors: None

Date Published: 27th Jan 2014

Journal: PLoS One

Abstract (Expand)

Expression of the catabolic network in Escherichia coli is predominantly regulated, via oxygen availability, by the two-component system ArcBA. It has been shown that the kinase activity of ArcB is ...

Authors: P. Sharma, S. Stagge, M. Bekker, K. Bettenbrock, K. J. Hellingwerf

Date Published: 7th Oct 2013

Journal: PLoS One

Abstract (Expand)

In Escherichia coli several systems are known to transport glucose into the cytoplasm. The main glucose uptake system under batch conditions is the glucose phosphoenolpyruvate:carbohydrate phosphotransferase ...

Authors: None

Date Published: 8th Oct 2012

Journal: Journal of Bacteriology

Abstract (Expand)

The respiratory chain of Escherichia coli contains three quinones. Menaquinone and demethylmenaquinone have low midpoint potentials and are involved in anaerobic respiration, while ubiquinone, which ...

Authors: Poonam Sharma, Joost Teixeira De Mattos, Klaas J. Hellingwerf, Martijn Bekker

Date Published: 1st Sep 2012

Journal: Not specified

Abstract (Expand)

Understanding gene regulation requires knowledge of changes in transcription factor (TF) activities. Simultaneous direct measurement of numerous TF activities is currently impossible. Nevertheless, ...

Authors: Matthew Rolfe, Andrea Ocone, Melanie R Stapleton, Simon Hall, Eleanor W Trotter, Robert Poole, Guido Sanguinetti, Jeff Green

Date Published: 8th Aug 2012

Journal: Open Biol

Abstract (Expand)

The respiratory chain of Escherichia coli contains three different cytochrome oxidases. Whereas the cytochrome bo oxidase and the cytochrome bd-I oxidase are well characterized and have been shown to ...

Authors: Poonam Sharma, Klaas J Hellingwerf, Maarten J Teixeira de Mattos, Martijn Bekker

Date Published: 27th Jul 2012

Journal: Appl. Environ. Microbiol.

Abstract (Expand)

Many of the complex systems found in biology are comprised of numerous components, where interactions between individual agents result in the emergence of structures and function, typically in a highly ...

Authors: Michael Holcombe, Salem Adra, Mesude Bicak, Shawn Chin, Simon Coakley, Alison Graham, Jeff Green, Chris Greenough, Duncan Jackson, Mariam Kiran, Sheila MacNeil, Afsaneh Maleki-Dizaji, Phil McMinn, Mark Pogson, Robert Poole, Eva Qwarnstrom, Francis Ratnieks, Matthew Rolfe, Rod Smallwood, Tao Sun, David Worth

Date Published: 2012

Journal: Integr Biol (Camb)

Abstract (Expand)

Many bacteria undergo transitions between environments with differing O₂ availabilities as part of their natural lifestyles and during biotechnological processes. However, the dynamics of adaptation ...

Authors: Eleanor W Trotter, Matthew Rolfe, Andrea M Hounslow, C Jeremy Craven, Michael P Williamson, Guido Sanguinetti, Robert Poole, Jeff Green

Date Published: 27th Sep 2011

Journal: PLoS ONE

Abstract:

Not specified

Authors: Sonja Steinsiek, S. Frixel, Stefan Stagge, Katja Bettenbrock

Date Published: 1st Jun 2011

Journal: Journal of Biotechnology

Abstract (Expand)

Oxygen availability is the major determinant of the metabolic modes adopted by Escherichia coli. Whilst much is known about E. coli gene expression and metabolism under fully aerobic and anaerobic ...

Authors: Matthew Rolfe, Alexander Ter Beek, Alison Graham, Eleanor W Trotter, H M Shahzad Asif, Guido Sanguinetti, Joost Teixeira De Mattos, Robert Poole, Jeff Green

Date Published: 22nd Jan 2011

Journal: Not specified

Abstract (Expand)

SUMMARY: TFInfer is a novel open access, standalone tool for genome-wide inference of transcription factor activities from gene expression data. Based on an earlier MATLAB version, the software has now ...

Authors: H M Shahzad Asif, Matthew Rolfe, Jeff Green, Neil D Lawrence, Magnus Rattray, Guido Sanguinetti

Date Published: 24th Aug 2010

Journal: Bioinformatics

Abstract (Expand)

Fumarate and nitrate reduction regulatory (FNR) proteins are bacterial transcription factors that coordinate the switch between aerobic and anaerobic metabolism. In the absence of O(2), FNR binds a ...

Authors: Adrian J Jervis, Jason C Crack, Gaye White, Peter J Artymiuk, Myles R Cheesman, Andrew J Thomson, Nick E Le Brun, Jeff Green

Date Published: 4th Mar 2009

Journal: Proc. Natl. Acad. Sci. U.S.A.

Abstract (Expand)

The concentration of molecular oxygen (O(2)) began to increase in the Earth's atmosphere approximately two billion years ago. Its presence posed a threat to anaerobes but also offered opportunities ...

Authors: Jeff Green, Jason C Crack, Andrew J Thomson, Nick E LeBrun

Date Published: 24th Feb 2009

Journal: Curr. Opin. Microbiol.

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