This model assumes a phenotypic switch between an acid- and solvent-forming population caused by the changing pH levels. The two phenotypes differ in their transcriptomic, proteomic, and ,thus, their metabolomic profile. Because the growth rates of these phenotypes depends on the extracellular pH, the initiation of the pH-shift results in a significant decline of the acidogenic population. Simultaneously, the solvent-forming population rises and establishes an new steady state.
The model is build
Contributor: Thomas Millat
Model type: Ordinary differential equations (ODE)
Model format: Matlab package
Organism: Clostridium acetobutylicum
Date Published: 3rd May 2013
Journal: Appl. Microbiol. Biotechnol.
PubMed ID: 23640360