With a background in the statistical mechanics of disordered systems, my research
focusses on the interface between statistical physics and molecular biology. At the centre is the relationship
between fluctuations and noise in biological systems, the corresponding statistical ensembles, and biological
function. This connection emerges at very different levels and timescales, from stochastic modeling of
gene expression to the population dynamics of regulatory DNA.
Bistable switches are the key elements of the regulatory networks governing cell development, differentiation and life-strategy decisions. Transcriptional noise is a main determinant that causes switching between different states in bistable systems. By using the human pathogen Streptococcus pneumoniae as a model bacterium, we will investigate how transcriptional fidelity and processivity influence (noisy) gene expression and participate in bistability. To study this question, we will use both
Date Published: 24th Sep 2014
Journal: Nucleic Acids Res
PubMed ID: 25245949
Authors: Michal Kolar, Jörn Meier, Ville Mustonen, Michael Lässig, Johannes Berg
Date Published: 21st Nov 2012
Journal: BMC Syst Biol
PubMed ID: 23171476
Authors: Lilia Perfeito, Stéphane Ghozzi, Johannes Berg, Karin Schnetz, Michael Lässig
Date Published: 21st Jul 2011
Journal: PLoS Genet.
PubMed ID: 21814515
Authors: Marta Łuksza, Michael Lässig, Johannes Berg
Date Published: 27th Nov 2009
Journal: Phys. Rev. Lett.
PubMed ID: 21231375