Professor of Biochemistry at the Centre of Biochemistry of Heidelberg University, teaching biochemistry for medical and biology students
Research focus is the trypanothione redox metabolism of African trypanosomes (Trypanosoma brucei).
The work is funded within the Collaborative Research Centre 544 on "Control of Tropical Infectious Diseases" of the German Research Foundation
The SilicoTryp project aims at the creation of a “Silicon Trypanosome”, a comprehensive, experiment-based, multi-scale mathematical model of trypanosome physiology.
Trypanosomes are blood-stream parasites transmitted by tsetse flies; they cause African sleeping sickness in humans and livestock. Currently available drugs have severe side effects, and the parasites are rapidly developing resistance.
In this project, we collect a wide range of new experimental data on the parasite in its various
This is a protocol for determining the activity of the T. brucei Trypanothione synthetase under in vivo-like conditions.
This method describes the preparation of the in vivo-like buffer for the measurement of bloodstream T. brucei recombinant enzymes under pseudo-physiological conditions.
Authors: Fiona Achcar, Abeer Fadda, Jurgen Haanstra, Eduard Kerkhoven, Dong-Hyun Kim, Alejandro Leroux, Federico Rojas, Barbara Bakker, Mike Barrett, Christine Clayton, Mark Girolami, Luise Krauth-Siegel, Keith Matthews, Rainer Breitling, Papamarkou T.
Date Published: 7th May 2014
Journal: Adv Microb Physiol
PubMed ID: 24797926
Date Published: 3rd Jul 2013
Journal: J. Biol. Chem.
PubMed ID: 23814051
Date Published: 6th May 2010
PubMed ID: 20444304