An ODE model representing the metabolic network governing acid and solvent production by Clostridium acetobutylicum (Haus et al. BMC Systems Biology 2011, 5:10), incorporating the effect of pH upon gene regulation and subsequent end-product levels. This model describes the second of four experiments in which the pH of the culture was shifted. For this experiment acidogenesis at pH 5.7 was maintained for 137.5 hours, after which the pH control was stopped, allowing the natural metabolic shift to the production of the solvents to begin.
Simulation link for JWS Online: http://jjj.mib.ac.uk/webMathematica/Examples/run.jsp?modelName=haus2
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Created: 12th Oct 2011 at 11:55
Last updated: 7th Mar 2012 at 13:46
Last used: 22nd May 2018 at 08:39