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- University of Cologne

**Web page: **http://www.pressoffice.uni-koeln.de/

**Country: ** Germany

**City: **Köln

**Address: **

University of Cologne

Universität zu Köln

Albertus-Magnus-Platz

50923 Köln

Tel.: +49 221 / 470-0

## Related items

**Projects:** Noisy-Strep

**Institutions:** University of Cologne

**Disciplines:** Not specified

**Roles:** Not specified

**Expertise:** Statistical Physics, Mathematical modelling

**Tools:** fortran, stochastic methods, Stochastic models, Mathematica, Matlab, Python

I am a phd student working on statistical physics and complex systems and applying concepts from these fields to biology.

**Projects:** Noisy-Strep

**Institutions:** University of Cologne

**Disciplines:** Not specified

**Roles:** Not specified

**Expertise:** Statistical Physics, Mathematical and statistical modeling

**Tools:** Statistical tools, stochastic methods, Dynamic modelling

With a background in the statistical mechanics of disordered systems, my research

focusses on the interface between statistical physics and molecular biology. At the centre is the relationship

between fluctuations and noise in biological systems, the corresponding statistical ensembles, and biological

function. This connection emerges at very different levels and timescales, from stochastic modeling of

gene expression to the population dynamics of regulatory DNA.

Bistable switches are the key elements of the regulatory networks governing cell development, differentiation and life-strategy decisions. Transcriptional noise is a main determinant that causes switching between different states in bistable systems. By using the human pathogen Streptococcus pneumoniae as a model bacterium, we will investigate how transcriptional fidelity and processivity influence (noisy) gene expression and participate in bistability. To study this question, we will use both

...

**Programme**: SysMO

**Public web page**: http://www.sysmo.net/index.php?index=163

**Organisms:** Streptococcus pneumoniae