-Relative metabolite measurements at different time points from all experiments
-Absolute metabolite measurements for amino-acid analysis of the proteome and the cytosol
-Effect on adding CaCl2, KCl or NaCl to the medium on growth
-Effect of spiking of growth medium with additional amino acids
Institutions: Wageningen University & Researchhttps://orcid.org/0000-0001-7049-5334
I am a researcher (PhD student) working at Wageningen University & Research as bioinformatician and modeller. I am working as part of the MycoSynVac (http://www.mycosynvac.eu/) project on dynamic modelling of central carbon metabolism in M. pneumoniae, to be extended to full dynamic modelling of metabolism to be implemented in a whole cell model.
I am also looking into possibilities to improve standards in model generation using semantic technologies, improving automatic generation, annotation
Institutions: CRG Centre for Genomic Regulationhttps://orcid.org/0000-0001-7568-4353
Universitat Autónoma de Barcelona : Barcelona, Spain
Institutions: CRG Centre for Genomic Regulationhttps://orcid.org/0000-0002-5276-1392
Luis Serrano did his PhD at the CBM (Madrid, Spain) on Cell Biology. Then he spent 4 years in the laboratory of Prof. A.R. Fehrs (MRC, UK) working in protein folding. In 1993, he became Group Leader at the EMBL (Heidelberg, Germany) working in Protein Folding and design. Ten years later, he was appointed head of the Structural & Computational Biology programme at the EMBL and he started to work on Systems Biology. By the end of 2006 he moved back to Spain to lead a programme working on Systems
The MycoSynVac project AIMS at using cutting-edge synthetic biology methodologies to engineer Mycoplasma pneumoniae as a universal chassis for vaccination.
Designing a universal Mycoplasma chassis that can be deployed as single- or multi-vaccine in a range of animal hosts. Annually, infections caused by Mycoplasma species in poultry, cows, and pigs result in multimillion Euro losses in the USA and Europe.
There is no effective vaccination against many Mycoplasmas that infect pets, humans and farm
Authors: Luis Serrano, Maier T.,Marcos J.,Wodke J. A.,Paetzold B.,Liebeke M.,Gutierrez-Gallego R.
Date Published: 20th Apr 2013
Journal: Mol Biosyst
PubMed ID: 23598864
Citation: Mol Biosyst. 2013 Jul;9(7):1743-55. doi: 10.1039/c3mb70113a. Epub 2013 Apr 19.
Date Published: 4th Apr 2013
Journal: Mol Syst Biol
PubMed ID: 23549481
Citation: Mol Syst Biol. 2013;9:653. doi: 10.1038/msb.2013.6.