External Coincidence Model - PLM_31, version 2
Model outputs mRNA expression of PIF4/5 that is under control of the Pokhilko extended circadian clock. The first version (Model 2a in the supplementary file) has inhibition of PIFs from TOC1. The second version (Model 2c) has PIF activity promoted by LHY/CCA1 - this is currently the most accurate model when compared to data. Models shall be updated later to include PIF4/5 protein levels. Parameter values for this and other External Coincidence models found in supplementary file.<br><br><strong>Version Comments</strong><p>
As stated in description for the previous version of External Coincidence model, this model links PIF activity to LHY/CCA1 in the Pokhilko Extended circadian clock. Due to lack of protein data, the parameters for this equation have not been optimised yet and will be done later. For two different sets of parameter values for this model based on different constraints see supplementary file (currently the unconstrained paramater set leads to the more accurate model).</p>
Originally submitted to PLaSMo on 2011-01-25 13:23:32
SEEK ID: https://fairdomhub.org/assays/862
Modelling Analysis
Projects: PlaSMo model repository
Investigation: Smith, Rob
Study: External Coincidence Model - PLM_31
Assay position:
Biological problem addressed: Gene Regulatory Network
Organisms: No organisms
Data:
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Created: 10th Jan 2019 at 16:40
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Projects: PlaSMo model repository
Institutions: University of Edinburgh
SynthSys is the University of Edinburgh's research organisation in interdisciplinary, Synthetic and Systems Biology, founded in 2012 as the successor to the Centre for Systems Biology at Edinburgh (CSBE).
Projects: Millar group, PHYTOCAL: Phytochrome Control of Resource Allocation and Growth in Arabidopsis and in Brassicaceae crops, TiMet, POP - the Parameter Optimisation Problem, Regulation of flowering time in natural conditions, PlaSMo model repository
Web page: http://www.synthsys.ed.ac.uk
What is PlaSMo? PlaSMo stands for Plant Systems-biology Modelling Ensuring the achievements of yesterday's Mathematical Modellers will be available for the Systems Biologists of tomorrow.
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To identify plant mathematical models useful to the UK plant systems biology community, which are currently in a variety of legacy formats and in danger of being lost
To represent these models in a declarative XML-based format, which is closer to the systems biology standard SBML To evaluate the behaviour ...
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Collection of models submitted to PLaSMo by Rob Smith and automatically transferred to FAIRDOM Hub.
Model outputs mRNA expression of PIF4/5 that is under control of the Pokhilko extended circadian clock. The first version (Model 2a in the supplementary file) has inhibition of PIFs from TOC1. The second version (Model 2c) has PIF activity promoted by LHY/CCA1 - this is currently the most accurate model when compared to data. Models shall be updated later to include PIF4/5 protein levels. Parameter values for this and other External Coincidence models found in supplementary file.Originally submitted ...
Submitter: BioData SynthSys
Investigation: Smith, Rob
Assays: External Coincidence Model - PLM_31, version 1, External Coincidence Model - PLM_31, version 2
