PGM
Kinetic characterisation en mathematical modelling of PGM.
SEEK ID: https://fairdomhub.org/assays/256
Modelling Analysis
Projects: Whole body modelling of glucose metabolism in malaria patients
Investigation: Glucose metabolism in Plasmodium falciparum trophozoites
Study: Model construction
Biological problem addressed: Model Analysis Type
Organisms: No organisms
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Created: 11th Aug 2014 at 09:35
Last updated: 8th Nov 2017 at 15:21
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orcid.org/0000-0003-2633-0537
Hypoglycaemia and lactic acidosis are key diagnostics for poor chances of survival in malaria patients. In this project we aim to test to what extent the metabolic activity of Plasmodium falciparum contributes to a changed glucose metabolism in malaria patients. The approach is to start with detailed bottom up models for the parasite and then merge these with more coarse grained models at the whole body level.
Programme: SARCHI: Mechanistic modelling of health and epidemiology
Public web page: Not specified
The investigation entails the construction and validation of a detailed mathematical model for glycolysis of the malaria parasite Plasmodium falciparum in the blood stage trophozoite form.
Snapshots: Snapshot 1
This study includes all the experimental data, SOPs and modelling files for the individual reactions used for the model construction.
Person responsible: Jacky Snoep
Snapshots: No snapshots
Experimental data for the phosphoglycerate mutase (EC 5.4.2.12) activity.
Creators: Dawie Van Niekerk, Jacky Snoep
Contributor: Dawie Van Niekerk
Relationship type: Construction data
Mathematica notebook for the parameterisation of the PGM rate equation based on SEEK linked experimental data.
Creators: Dawie Van Niekerk, Jacky Snoep
Contributor: Dawie Van Niekerk
Model type: Ordinary differential equations (ODE)
Model format: Mathematica
Environment: Not specified
SOP for measurement of PGM activity in extracts.
Creators: Dawie Van Niekerk, Jacky Snoep
Contributor: Dawie Van Niekerk
